Persistent Platelet Reactivity in Acute Coronary Syndrome

Completed

• Conditions: Acute Coronary Syndrome

• Registration Number: NCT02038309
• Lead Sponsor: Hopital Lariboisière

Brief Summary

Study of persistent platelet reactivity during acute coronary syndrome. Patients are included at admission to the hospital. Platelet aggregation is evaluated by platelet function testing after blood sampling during hospitalization. No changes in treatment is planned.

Detailed Description

Blood samples are performed on day 2 and 4 and collected with usual blood samples and analyzed by the laboratory. Maximal aggregation intensity and velocity are measured by light transmission aggregometry induced by arachidonic acid (AA) or adenosine diphosphate (ADP). Platelet function analyzer will be also used. No changes in treatment in response to the results is planned.

Study Timeline

• Study Start: 2013-01
• Primary Completion: 2013-12
• Status Verified: 2014-01
• Study First Submitted: 2014-01-12
• Study First Submitted QC: 2014-01-14
• Study First Posted: 2014-01-16
• Study Completion: 2015-12
• Last Update Submitted: 2024-07-24
• Last Update Posted: 2024-07-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 106

Inclusion Criteria

• acute coronary syndrome with elevation in troponin

Exclusion Criteria

• anticoagulant treatment

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
maximum aggregation intensity	day 2	Light transmission aggregometry following exposition to arachidonic acid 0.5mg/ml during the acute phase (day2-day 5)

Secondary Outcome Measures

Name	Time	Method
Maximum aggregation intensity	Chronic phase (day 30 to day 60)	Light transmission aggregometry following exposition to arachidonic acid 0.5mg/ml during the chronic phase (day 30-day 60)

Trial Locations

Locations (1)

Department of Cardiology - Lariboisiere Hospital; 🇫🇷 Paris, France