Pupillary Response After Glaucoma Medication

Not Applicable

Completed

• Conditions: Drug Effect (Glaucoma Drugs)
• Interventions: Drug: Latanoprost; Drug: Timolol; Drug: Dorzolamide

• Registration Number: NCT02522039
• Lead Sponsor: Glostrup University Hospital, Copenhagen

Brief Summary

Investigation of the effect on the pupillary constriction by latanoprost, dorzolamide,timolol in healthy subjects. The pupillary constriction is compared to no drug.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-05
• Primary Completion: 2014-11
• Study Completion: 2014-11
• Study First Submitted: 2014-11-14
• Status Verified: 2015-08
• Study First Submitted QC: 2015-08-11
• Last Update Submitted: 2015-08-11
• Study First Posted: 2015-08-13
• Last Update Posted: 2015-08-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• healthy subjects

Exclusion Criteria

• ophthalmological diseases
• systemic disease
• smoking
• refractive error >= 6 diopters

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Latanoprost	Latanoprost	solution, 1 drop of 50ug/ml latanoprost, was given to study eye after washout period of 1 week between drugs
Timolol	Timolol	solution, 1 drop of 5mg/ml timolol , was given to study eye after washout period of 1 week between drugs
dorzolamide	Dorzolamide	solution, 1 drop of 20 mg/ml dorzolamide, was given to study eye after washout period of 1 week between drugs

Primary Outcome Measures

Name	Time	Method
pupillary constriction measured as the post-illimination pupillay response (PIPR)	1 day	The pupillary diameter 0 to 10 seconds after light stimulation, the diameter is measured relative to the initial dark adapted pupil diameter

Trial Locations

Locations (1)

Glostrup University Hospital; 🇩🇰 Glostrup, Denmark