Effect of Topical Anti-glaucoma Medications on Late Pupillary Light Reflex, as Evaluated by Pupillometry
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- pupillary constriction measured as the post-illimination pupillay response (PIPR)
研究概览
简要总结
Investigation of the effect on the pupillary constriction by latanoprost, dorzolamide,timolol in healthy subjects. The pupillary constriction is compared to no drug.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy subjects
排除标准
- •ophthalmological diseases
- •systemic disease
- •refractive error >= 6 diopters
研究组 & 干预措施
Latanoprost
solution, 1 drop of 50ug/ml latanoprost, was given to study eye after washout period of 1 week between drugs
干预措施: Latanoprost (Drug)
Timolol
solution, 1 drop of 5mg/ml timolol , was given to study eye after washout period of 1 week between drugs
干预措施: Timolol (Drug)
dorzolamide
solution, 1 drop of 20 mg/ml dorzolamide, was given to study eye after washout period of 1 week between drugs
干预措施: Dorzolamide (Drug)
结局指标
主要结局
pupillary constriction measured as the post-illimination pupillay response (PIPR)
时间窗: 1 day
The pupillary diameter 0 to 10 seconds after light stimulation, the diameter is measured relative to the initial dark adapted pupil diameter
次要结局
未报告次要终点
研究者
Birgit Sander
md
Glostrup University Hospital, Copenhagen