Effects of Remote Ischemic Conditioning on Blood Pressure in Older Patients With Hypertension
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 158
- Locations
- 1
- Primary Endpoint
- Mean systolic blood pressure
Study Overview
Brief Summary
The purpose of this study is to learn about effects of remote ischemic conditioning on blood pressure in older patients with essential hypertension.
Detailed Description
Current studies have shown that remote ischemic conditioning can improve vascular endothelial function and inhibit sympathetic nervous system activity. Thus it may provide some organ protection as well as anti-hypertensive effects. The purpose of this study is to learn about effects of remote ischemic conditioning on blood pressure in older patients with essential hypertension.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Outcomes Assessor)
Eligibility Criteria
- Ages
- 65 Years to 85 Years (Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age ≥65 years and ≤85 years, regardless of gender;
- •History of essential hypertension and clinical systolic blood pressure ≥ 140 mmHg, regardless of whether they are receiving antihypertensive medication;
- •Willing to participate and sign the informed consent.
Exclusion Criteria
- •Secondary hypertension;
- •Clinical blood pressure ≥ 180/110 mmHg or 24-hour mean arterial pressure ≥ 170/100 mmHg;
- •Severe organ dysfunction or failure;
- •Severe hematologic disorders or significant coagulation abnormalities;
- •History of atrial fibrillation or myocardial infarction within 6 months;
- •Individuals who had contraindication of remote ischemic conditioning, such as severe soft tissue injury, fracture or vascular injury in the upper limb, acute or subacute venous thrombosis, arterial occlusive disease, subclavian steal syndrome, etc;
- •Individuals who will or have received anticoagulant therapy with drugs such as dabigatran, rivaroxaban, warfarin, etc;
- •Those who are participating in other clinical research or has participated in other clinical research or has participated in this study within 3 months prior to enrollment;
- •Other conditions that the researchers think are not suitable for the project.
Arms & Interventions
RIC group
Patients are treated with remote ischemic conditioning (RIC).
Intervention: Remote ischemic conditioning (Procedure)
Sham RIC group
Patients are treated with sham remote ischemic conditioning (sham-RIC).
Intervention: Sham remote ischemic conditioning (Procedure)
Outcomes
Primary Outcomes
Mean systolic blood pressure
Time Frame: 0-7 days
Difference in mean value of systolic blood pressure during RIC/sham-RIC between two groups.
Secondary Outcomes
- Mean diastolic blood pressure(0-7 days)
Investigators
Yi Yang
Vice President of First Hospital of Jilin University
The First Hospital of Jilin University