Remote Ischemic Conditioning and Platelet Dysfunction
- Conditions
- Platelet Function
- Interventions
- Procedure: Remote ischemic conditioningProcedure: Control
- Registration Number
- NCT03125681
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
The purpose of this study is to evaluate the effects of remote ischemic conditioning on platelet function during off-pump coronary artery bypass surgery.
- Detailed Description
Remote ischemic conditioning (RIC) may affect platelet function. However, little is known about effect of RIC on platelet function during off-pump coronary artery bypass surgery. In this study investigators are going to perform RIC after anesthesia induction (remote ischemic pre-conditioning) and after completion of coronary anastomoses (remote ischemic post-conditioning), and compare platelet function parameters with control group.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 58
- 20 - 80 years of adult patient undergoing elective off-pump coronary artery bypass surgery
- Acute Myocardial Infarction
- Recent (<1 month) coronary angioplasty (percutaneous coronary intervention, PCI)
- Acute cerebrovascular ischemia (<6 months)
- Preoperative LV EF < 30%, mechanical ventricular support (IABP, VAD, ECMO)
- Peripheral vascular disease
- Poorly controlled diabetes mellitus
- Alzheimer's disease
- NSAIDs within 3 days
- iv heparin within 6 h
- low molecular weight heparin within 24 h
- platelet inhibitor within 24 h
- known thrombocytopenia
- renal failure / hemodialysis
- active infection
- preoperative bleeding diathesis
- redo-operation
- pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Remote ischemic conditioning Remote ischemic conditioning Applying pneumatic cuff on upper extremity (5 minutes cycles of limb ischemia and reperfusion with pneumatic cuff up to 200 mmHg repeated by four times) before and after coronary anastomoses. Control Control All the procedures were the same in the control group, except for the fact that the three-way stopcock between the pneumatic cuff and the cuff inflator was opened and therefore the cuff pressure did not increase.
- Primary Outcome Measures
Name Time Method Change of Multiplate ADPtest AUC Baseline, at the end of surgery, postoperative day 1 Area under the aggregation curve (AUC) after platelet stimulation with adenosine diphosphate
- Secondary Outcome Measures
Name Time Method Change of Multiplate ASPItest AUC Baseline, at the end of surgery, postoperative day 1 Area under the aggregation curve (AUC) after platelet stimulation with arachidonic acid
Change of Multiplate COLtest AUC Baseline, at the end of surgery, postoperative day 1 Area under the aggregation curve (AUC) after platelet stimulation with collagen
Change of Rotational thromboelastometry EXTEM parameter Baseline, at the end of surgery, postoperative day 1 Screening test for the extrinsic haemostasis system
Change of Rotational thromboelastometry HEPTEM parameter Baseline, at the end of surgery, postoperative day 1 Represents an INTEM assay performed in the presence of heparinase
Change of Rotational thromboelastometry FIBTEM parameter Baseline, at the end of surgery, postoperative day 1 Represents an EXTEM based assay for the fibrin part of the clot
Rotational thromboelastometry INTEM parameter Baseline, at the end of surgery, postoperative day 1 Intrinsically activated rotational thrombelastometry
Amount of peri-operative bleeding and transfusion At the end of surgery, postoperative day 1,2,3 Amount of peri-operative bleeding and transfusion
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of