Effect of Sodium NItroprusside (SNP) on R,S] and S]Ketamine]induced psychotropic side effects, hemodynamic changes and pain relief in healthy volunteers
Recruiting
- Conditions
- Psychomimetic side effects ketamine
- Registration Number
- NL-OMON23422
- Lead Sponsor
- MC anesthesiology department
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 26
Inclusion Criteria
Male subjects, aged 18]34 years with a body mass index < 30 kg/m2
Exclusion Criteria
Severe medical disease including hypertension, liver/renal disease, neurological disorders, diaphragmatic hernia/pyrosis; (history of) psychiatric or neurological disease; allergy to study medication; (history of) illicit drug abuse/alcoholism.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method psychomimetic side effects evaluated by Bowdle and Bond & Lader.
- Secondary Outcome Measures
Name Time Method -Hemodynamic response as evaluated by mean arterial pressure and cardiac output.<br /><br>- Analgesia (pressure and electrical)<br /><br>-Arterial blood samples (pharmacokinetic study)