Effect of Sodium NItroprusside (SNP) on R,S- and S-Ketamine-induced psychotropic side effects, hemodynamic changes and pain relief in healthy volunteers

Completed

• Conditions: chronische (neuropathische) pijn; Chronic Pain; neuropathic pain

• Registration Number: NL-OMON43889
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Trial is onging in other countries

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2017-08-24
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 36

Inclusion Criteria

Male subjects, aged 18-34 years with a body mass index < 30 kg/m2.

Exclusion Criteria

Severe medical disease including hypertension, liver/renal disease, neurological disorders, diaphragmatic hernia/pyrosis; (history of) psychiatric or neurological disease; allergy to study medication; (history of) illicit drug abuse/alcoholism.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Psychedelic and negative effects are measured using visual analog scales<br /><br>ranging from 0 (no effect) to 10 cm (maximum effect) of the Bowdle and Bond &<br /><br>Lader questionnaires (Appendix 1A and B).11,12 </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Pain relief from ketamine (S vs RS) and placebo vs SNP.</p><br>