THE EFFECT OF DIETARY NITRATE AND SUCROSE ON GI FUNCTION DURING EXERCISE

Completed

• Conditions: GI function (intestinal damage and blood flow) during exercise; intestinal blood flow; intestinal damage

• Registration Number: NL-OMON43091
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Trial is onging in other countries

Detailed Description

Not available

Study Timeline

• Study Completion: 2017-05-11
• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

- Healthy (see exclusion criteria below)
- 18 - 40 years of age
- 18.5 < BMI < 30 kg/m2
- Engagement in regular cycling activity (at least 2x per wk)
- Wmax > 4.5 W/kg

Exclusion Criteria

- Diagnosed or on medication for: Cardiovascular disease; Chronic Obstructive Pulmonary Disease (COPD); Rheumatoid arthritis (RA); Inflammatory bowel disease (IBD); Morbus Crohn and colitis ulcerosa; Irritable bowel syndrome; Inflammatory systemical diseases; Diabetes Mellitus; Diabetes Insipidus; Hypo- or hyperthyreoidism; Kidney failure; Donation of blood within the last 3 months; Cancer, Alcohol use of > 5 units per day; Drugs abuse; Use of regular medication; Oversensitive for sucrose; Phenol Keton Uria (PKU); Acute porphyria in the past.
- Smoking
- Currently supplementing diet with nitrate

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Intestinal damage: plasma intestinal fatty acid binding protein (I-FABP)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>GI perfusion: gastric tonometry<br /><br>Plasma nitrate and nitrite<br /><br>Plasma glucose<br /><br>Resting blood pressure</p><br>