EFFECT OF INCREASING DIETARY NITRATE INTAKE BY DIETARY INTERVENTION ON BLOOD PRESSURE IN (PRE)HYPERTENSIVE MEN AND WOME

Completed

• Conditions: hypertentie; blood pressure; Pharmacokinetics

• Registration Number: NL-OMON48183
• Lead Sponsor: Hogeschool van Arnhem en Nijmegen

Brief Summary

Trial is onging in other countries

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-09-01
• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 81

Inclusion Criteria

- Elevated blood pressure or stage 1 hypertension:
Elevated blood pressure. Elevated blood pressure is a systolic pressure ranging from 120 to 129 mm Hg and a diastolic pressure below 80 mm Hg. Elevated blood pressure tends to get worse over time unless steps are taken to control blood pressure.
Stage 1 hypertension. Stage 1 hypertension is a systolic pressure ranging from 130 to 139 mm Hg or a diastolic pressure ranging from 80 to 89 mm Hg.
- Current vegetable intake <200 g/d based on FFQ;
- Registered for the Nijmegen Four Days Marches 2019;
- 18.5 < BMI * 35.0 kg/m2;
- Able to understand and perform the study procedures.

Exclusion Criteria

- Use of medication (with known vasoactive properties);
- Currently smoking
- Currently supplementing diet with nitrate.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main aim of the current study is to investigate the effect of a 12 week<br /><br>dietary intervention focusing on increasing vegetable intake on 24h blood<br /><br>pressure. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Plasma concentrations: plasma nitrate and nitrate, plasma cholesterol, HDL,<br /><br>LDL, triglyceride, troponin I;<br /><br>- Dietary intake: total macro- and micronutrient intake, vegetable and dietary<br /><br>nitrate intake;<br /><br>- Blood pressure and heart rate<br /><br>- Submaximal aerobic endurance exercise</p><br>