EFFECT OF INCREASING DIETARY NITRATE INTAKE BY DIETARY INTERVENTION ON BLOOD PRESSURE IN (PRE)HYPERTENSIVE MEN AND WOME
- Conditions
- hypertention
- Registration Number
- NL-OMON21682
- Lead Sponsor
- -
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 87
Prehypertension or hypertension:
Prehypertension is a systolic and/or diastolic pressure above 131/86 – 139/89 mmHg. Hypertension is a systolic and/or diastolic pressure above 140/90mmHg [22]. When one of the two is equal to or higher than 131-86, the participant will be included.
-Current vegetable intake <200 g/d based on FFQ;
-Registered for the Nijmegen Four Days Marches 2019;
-18.5 < BMI = 35.0 kg/m2;
-Able to understand and perform the study procedures.
-Chronic use of medication or products with known vasoactive properties and chronic use of the following products: [63, 64];
NSAIDs (including acetylsalicylic acid and selective COX-2 inhibitors)
sympathomimetics (decongestants, sibutramine, cocaine)
Alcohol
glycyrretic acid-containing products (including licorice, liquorice and some chewing gums)
erythropoietin
cyclosporine
timulants ((dex) methylphenidate, (dextroof with) amphetamine, modafinil)
some herbs (ephedra, ma huang)
-Currently smoking [23];
-Currently supplementing diet with nitrate.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 24h blood pressure
- Secondary Outcome Measures
Name Time Method -Plasma concentrations: plasma nitrate and nitrate, plasma cholesterol, HDL, LDL, triglyceride, troponin I;<br>-Dietary intake: total macro- and micronutrient intake, vegetable and dietary nitrate intake;<br>-Blood pressure and heart rate at rest, during submaximal exercise and orthostatic resonse<br>-Exhaled nitric oxide;<br>