Effect of Long-Term Dietary Nitrate Intake on health parameters in individuals undergoing Physical Activity

Not Applicable

Recruiting

• Conditions: Vascular Diseases; diabetes mellitus; Endocrine System Diseases

• Registration Number: RBR-87qh649
• Lead Sponsor: niversidade Federal do Rio de Janeiro Campus Macaé

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-03-27
• Last Update Posted: 19 August 2024
• Study Completion: 2026-10-01

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Adults aged between 18-45; both sexes; physically active. Apparently healthy elderly people (over 60 years old); both sexes; eutrophic; physically active. unhealthy elderly (over 60 years old); both sexes; overweight; physically active; with the presence of one or more of the following clinical conditions: high triglycerides; high-density lipoprotein reduced cholesterol; increased waist circumference; high fasting blood sugar

Exclusion Criteria

Adults with cardiovascular diseases; inflammatory bowel diseases; lung disease; diabetes mellitus; hypertension; dyslipidemia; smoking; urinary infection; pregnant women; lactating women; using drugs that interfere with amino acid metabolism or nitric oxide production; use of antibiotics, anti-inflammatory; use of prebiotics, probiotics or synbiotics; the presence of osteomioarticular lesions in 3 months; use of nutritional ergogenics; use of mouthwash. Apparently healthy elderly people without a diagnosis of cardiovascular disease, inflammatory bowel disease, lung disease, diabetes mellitus, hypertension, dyslipidemia and urinary tract infection; smoking; pregnant women, lactating women; using drugs that interfere with amino acid metabolism or NO production; use of antibiotics, anti-inflammatory; use of prebiotics, probiotics or synbiotics; use of nutritional ergogenics; use of mouthwash; the presence of osteomioarticular lesions in 3 months. Unhealthy elderly people with any other pathology not previously described; use of antibiotics, anti-inflammatory; use of prebiotics, probiotics or synbiotics; use of nutritional ergogenics; use of mouthwash; the presence of osteomioarticular lesions in 3 months

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
It is expected to find, after long-term ingestion of a compound rich in nitrate and the practice of physical exercise, an improvement of the macro and microvascular endothelial function of the volunteers through the technique of flow-mediated dilation of the arteries; the improvement of performance parameters and muscle quality, through the isokinetic dynamometer and ultrasonography; increased angiogenesis and the modification of biochemical parameters and the composition of short-chain fatty acids in biological samples through analysis by gas chromatography

Secondary Outcome Measures

Name	Time	Method
It is expected to find, after long-term ingestion of a nitrate-rich compound and physical exercise, the modification of body composition