The Relationship Between Genetic Polymorphism of Arsenic Methylation Enzymes, Arsenic Methylation Capability and Blood Metals, and Developmental Delays in Preschool Children
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Taipei Medical University
- Enrollment
- 137
- Locations
- 1
- Primary Endpoint
- heavy metal assessment
Study Overview
Brief Summary
The purpose of this study is to explore the relationship between arsenic methylation and blood metals in children with developmental delays and its correlation with health related quality of life.
Detailed Description
The investigators recruited children with developmental delays and children with normal development from Shin-Kong Ho-Su Memorial Hospital as controls. Information obtained from the interview included socioeconomic and basic demographic characteristics as well as children function, health condition, and quality of life. On the other hand, blood and urine samples of the participants were collected for the analysis of arsenic methylation related enzymes using polymerase chain reaction and restriction fragment length polymorphism. 2 ml blood were digested for the determination of mercury, lead and arsenic. The relationship between arsenic methylation and blood metals in children with developmental delays and its correlation with health related quality of were analyzed.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 2 Years to 12 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •children with developmental delays obtained written informed consent from parents
Exclusion Criteria
- •parents refused for participation of their children to the intervention failed to obtain the written informed consent from parents
- •Control group:
- •Inclusion Criteria:
- •children with normal development obtained written informed consent from parents
- •Exclusion Criteria:
- •parents refused for participation of their children to the intervention failed to obtain the written informed consent from parents
Outcomes
Primary Outcomes
heavy metal assessment
Time Frame: 3 months
laboratory analysis
Secondary Outcomes
- quality of life(2 weeks)
Investigators
Ru-Lan Hsieh
Associate Professor
Taipei Medical University