The effects of NAD+-precursor supplementation on energy metabolism in physically compromised elderly.
- Conditions
- veroudering, energiemetabolisme.Ageing
- Registration Number
- NL-OMON47902
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 36
- Males and females
- Age * 65 * 80 years;
- BMI * 20 kg/m2 * 30 kg/m2;
- Normal physical activity levels: maximum of 1 hour per week engagement in a structured exercise session;
- 6-minute walking distance of 465 meters or less;
- Subject should be in sufficient health to participate in the experiments, to be judged by the responsible physician based on the subject's medical history.
- Not meeting all inclusion criteria;
- Smoking;
- Excessive alcohol use and/or drug abuse;
- Subjects with diabetes mellitus type 2;
- Significant food allergies or intolerances concerning the study products;
- Participation in another biomedical study within 1 month before the first study visit, possibly interfering with the study results;
- Medication use known to hamper subject*s safety during the study procedures;
- Subjects who use selective serotonin re-uptake inhibitors (SSRI), or selective norepinephrin re-uptake inhibitors (SNRI), or monoamino oxidase inhibitors (MAO-inhibitors), or clomipramine, or St. John*s wort (Hypericum perforatum);
- Subjects with contra-indications for MRI;
- Subjects who do not want to be informed about unexpected medical findings;
- Subjects who do not want that their treating physician to be informed;
- Co-morbidities to which the intervention or program the may pose as a complicating factor;
- Inability to participate and/or complete the required measurements.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main outcome parameters relate to the anticipated differences in<br /><br>mitochondrial function and include ex vivo mitochondrial respiratory capacity,<br /><br>in vivo mitochondtrial capacity, resting- and exercising energy metabolism, and<br /><br>in vivo mitochondrial capacity. </p><br>
- Secondary Outcome Measures
Name Time Method <p>- Glucose tolerance;<br /><br>- Physical performance;<br /><br>- Intramuscular cellular lipid content;<br /><br>- Hepatic fat;<br /><br>- Physical activity;<br /><br>- Quality of life;<br /><br>- Markers of mitochondrial metabolism.<br /><br>- Blood metabolites and biomarkers.</p><br>