Nasolacrimal Sac Biopsy in Endoscopic Dacryocystorhinostomy

Completed

• Conditions: Dacryocystitis; Chronic

• Registration Number: NCT04793230
• Lead Sponsor: Al-Azhar University

Brief Summary

During dacryocystorhinostomy (DCR), the lacrimal sac wall biopsy is not routinely performed, but it is recommended if there is a suspicion of underlying disease other than preoperatively or intraoperatively chronic inflammation. We aimed to evaluate the utility of the histopathology examination of fifty patients in AlAzhar Hospitals to put recommendation for histopathology examination of such cases.

Detailed Description

Most of patient with epiphora have different causes of nasolacrimal duct obstruction . This study aims to examine how important routine lacrimal sac biopsy is during endoscopic dacryocystorhinostomy surgery.

The study included 50 patients with chronic unilateral epiphora. All patients underwent endoscopic dacryocystorhinostomy with nasolacrimal duct biopsy. Histopathologic analysis was performed for each specimen to assess the nature of the pathology.

Study Timeline

• Study Start: 2019-01-01
• Primary Completion: 2020-12-30
• Status Verified: 2021-03
• Study First Submitted: 2021-03-08
• Study Completion: 2021-03-09
• Study First Submitted QC: 2021-03-09
• Last Update Submitted: 2021-03-09
• Study First Posted: 2021-03-11
• Last Update Posted: 2021-03-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Male and female patients with chronic lacrimal duct obstruction attended the outpatient clinic of the hospital for treatment during the study period.

Exclusion Criteria

• Patients refusing the biopsy
• Patients asked for histopathology in private laboratories

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Microscopic examination using Hematoxylin and Eosin stains with special stain	fourteen days	sending the biopsies to the pathology laboratory with completed request form then examination of the biopsies in the laboratory using the light microscope to assess the nature of the lesion with degree of inflammation according to the amount of lymphocytes to be classified as mild (10% cells), moderate (up to 50%) or severe (more than 50% lymphocytic cells)

Trial Locations

Locations (1)

Azhar faculty of medicine; 🇪🇬 Cairo, Egypt