Cross-sectional Study of Use of Speckle Method in Early Diagnosis of Cardiovascular Dysfunction
- Conditions
- Sjogren Syndrome
- Registration Number
- NCT02132585
- Lead Sponsor
- University of Roma La Sapienza
- Brief Summary
Speckle tracking (STE) is a novel echocardiographic technique which permits calculation of myocardial velocities and deformation parameters such as strain and strain rate (SR). It is demonstrated that these parameters provide important insights into systolic and diastolic function, ischaemia, myocardial mechanics and many other pathophysiological processes of the heart. In this preliminary study, we investigated the role of STE in detection of early ventricular dysfunction in patients with Sjogren Syndrome, focusing on cardiorespiratory fitness.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 700
- Diagnosis of Sjogren Syndrome
- previous cardiovascular events
- unstable angina
- stroke
- diagnosis of heart failure
- incapacity to provide an informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Longitudinal Myocardial Strain reduction in Sjogren Patients Baseline, 24 weeks Longitudinal Myocardial Strain reduction could be an early marker of cardiac dysfunction in patients with Sjogren Syndrome, significantly better than common measurement (such as ejection fraction)
- Secondary Outcome Measures
Name Time Method Association between 6minute-walking-test and Longitudinal strain reduction baseline, 24 weeks Longitudinal strain reduction could be linked to decrease in cardiorespiratory fitness, especially in 6-minute-walking-test
Trial Locations
- Locations (2)
Galeazzi IRCCS of Milan
🇮🇹Milan, Italy
Sapienza University
🇮🇹Rome, Italy
Galeazzi IRCCS of Milan🇮🇹Milan, Italy