Cross Sectional Study of Use of Speckle Tracking Echocardiography in the Early Diagnosis of Cardiovascular Dysfunction and Performance in Sjogren Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sjogren Syndrome
- Sponsor
- University of Roma La Sapienza
- Enrollment
- 700
- Locations
- 2
- Primary Endpoint
- Longitudinal Myocardial Strain reduction in Sjogren Patients
- Last Updated
- 11 years ago
Overview
Brief Summary
Speckle tracking (STE) is a novel echocardiographic technique which permits calculation of myocardial velocities and deformation parameters such as strain and strain rate (SR). It is demonstrated that these parameters provide important insights into systolic and diastolic function, ischaemia, myocardial mechanics and many other pathophysiological processes of the heart. In this preliminary study, we investigated the role of STE in detection of early ventricular dysfunction in patients with Sjogren Syndrome, focusing on cardiorespiratory fitness.
Investigators
Gianturco Luigi
MD
University of Roma La Sapienza
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of Sjogren Syndrome
Exclusion Criteria
- •previous cardiovascular events
- •unstable angina
- •diagnosis of heart failure
- •incapacity to provide an informed consent
Outcomes
Primary Outcomes
Longitudinal Myocardial Strain reduction in Sjogren Patients
Time Frame: Baseline, 24 weeks
Longitudinal Myocardial Strain reduction could be an early marker of cardiac dysfunction in patients with Sjogren Syndrome, significantly better than common measurement (such as ejection fraction)
Secondary Outcomes
- Association between 6minute-walking-test and Longitudinal strain reduction(baseline, 24 weeks)