Cross Sectional Study of Use of Speckle Tracking Echocardiography in the Early Diagnosis of Cardiovascular Dysfunction and Performance in Sjogren Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 700
- 试验地点
- 2
- 主要终点
- Longitudinal Myocardial Strain reduction in Sjogren Patients
研究概览
简要总结
Speckle tracking (STE) is a novel echocardiographic technique which permits calculation of myocardial velocities and deformation parameters such as strain and strain rate (SR). It is demonstrated that these parameters provide important insights into systolic and diastolic function, ischaemia, myocardial mechanics and many other pathophysiological processes of the heart. In this preliminary study, we investigated the role of STE in detection of early ventricular dysfunction in patients with Sjogren Syndrome, focusing on cardiorespiratory fitness.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of Sjogren Syndrome
排除标准
- •previous cardiovascular events
- •unstable angina
- •diagnosis of heart failure
- •incapacity to provide an informed consent
结局指标
主要结局
Longitudinal Myocardial Strain reduction in Sjogren Patients
时间窗: Baseline, 24 weeks
Longitudinal Myocardial Strain reduction could be an early marker of cardiac dysfunction in patients with Sjogren Syndrome, significantly better than common measurement (such as ejection fraction)
次要结局
- Association between 6minute-walking-test and Longitudinal strain reduction(baseline, 24 weeks)
研究者
Gianturco Luigi
MD
University of Roma La Sapienza