Effect of carvedilol on norepinephrine levels in hemodialysis patients

Not Applicable

Completed

• Conditions: Cardiovascular disease in hemodialysis patients; Circulatory System

• Registration Number: ISRCTN16564394
• Lead Sponsor: niversity of Sao Paulo

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2005-08-01
• Study Start: 2020-09-02
• Last Update Posted: 14 September 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

1. 18 years or older
2. Having chronic kidney disease (CKD)
3. Having been on regular hemodialysis for more than 6 months
4. Having a hemoglobin level >10 mg/dl
5. Having a Kt/V >1.2 in more than three consecutive measures
6. Patients gave written informed consent

Exclusion Criteria

1. Active liver disease
2. Any other decompensated disease
3. Previously used beta-blockers
4. Active infection
5. Hospitalized

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean plasma norepinephrine level measured by High Performance Liquid Chromatography (HPLC) at 0 and 14 days

Secondary Outcome Measures

Name	Time	Method
umber of ventricular arrhythmias registered by Holter monitoring at 0 and 14 days