The Therapeutic Effect of Exercise Training on Old Patients With Dementia and Mild Cognitive Impairment: A Randomized Controlled Trial
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Dementia
- Sponsor
- Taichung Veterans General Hospital
- Enrollment
- 107
- Locations
- 1
- Primary Endpoint
- Geriatric Depression Scale
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This study aimed to clarify whether strength training or aerobic training could bring more benefits for patients with dementia, another study is to clarify whether isokinetic or isotonic training could bring more benefits for patients with mild cognitive impairment
Detailed Description
Exercise training has been evidenced to bring various of benefits for patients with dementia in past studies. However, whether strength training or aerobic training could bring better benefits has not been confirmed in the past. This study designed to recruit 30 patients with mild dementia in the first year. Every patient will receive strength training using dumbbells, butterfly machine and vertical leg press machine for four weeks. Outcome measures including self care ability, cognitive function, MCP-1, BDNF and IGF-1 levels, and the degree of depression will be recorded before and after the training. In the second year, the investigators also designed to recruit 31 patients with mild dementia. These participants will instead receive aerobic training using stationary bicycle for four weeks. The same outcome measures will be tested as in the first year. The other part of the study recruited 46 patients with mild cognitive impairment, who were randomized into either a four-week isokinetic or isotonic training program. All cases were evaluated by isokinetic peak torque, 36-item Short Form Survey (SF-36), Mini-Mental State Examination (MMSE), Barthel Index, geriatric depression scale (GDS-15), and Timed Up and Go test (TUG test) before and after each kind of training.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Geriatric Depression Scale
Time Frame: 4 weeks
To evaluate patient's depression status, range from 0-15, higher values represent a worse outcome
SF-36
Time Frame: 4 weeks
consists of 36 questions categorized into 8 subdomains, including physical functioning, role limitations due to physical health, pain, general health condition, vitality, social functioning, role limitations due to emotional problems, and emotional well-being.
Mini-mental state examination
Time Frame: 4 weeks
To evaluate cognitive function, range from 0-30, higher values represent a better outcome
Montreal Cognitive Assessment
Time Frame: 4 weeks
To evaluate cognitive function, range from 0-30, higher values represent a better outcome
Barthel index
Time Frame: 4 weeks
To evaluate function of activities of daily living, range from 0-100, higher values represent a better outcome
Timed up and go test
Time Frame: 4 weeks
Measure the time taken by a patient to stand up from a chair, walk three meters, return, and sit back on the chair
Secondary Outcomes
- Concentration of serum brain derived neurotrophic factor (BDNF)(4 weeks)
- Concentration of plasma insulin-like growth factor-1 (IGF-1)(4 weeks)
- Concentration of plasmamonocyte chemotactic protein-1 (MCP-1)(4 weeks)