The Therapeutic Effect of Exercise Training on Patients With Dementia and Mild Cognitive Impairment
- Conditions
- Dementia
- Interventions
- Device: Isotonic trainingDevice: Isokinetic trinaingDevice: Strength trainingDevice: Aerobic training
- Registration Number
- NCT03811314
- Lead Sponsor
- Taichung Veterans General Hospital
- Brief Summary
This study aimed to clarify whether strength training or aerobic training could bring more benefits for patients with dementia, another study is to clarify whether isokinetic or isotonic training could bring more benefits for patients with mild cognitive impairment
- Detailed Description
Exercise training has been evidenced to bring various of benefits for patients with dementia in past studies. However, whether strength training or aerobic training could bring better benefits has not been confirmed in the past. This study designed to recruit 30 patients with mild dementia in the first year. Every patient will receive strength training using dumbbells, butterfly machine and vertical leg press machine for four weeks. Outcome measures including self care ability, cognitive function, MCP-1, BDNF and IGF-1 levels, and the degree of depression will be recorded before and after the training. In the second year, the investigators also designed to recruit 31 patients with mild dementia. These participants will instead receive aerobic training using stationary bicycle for four weeks. The same outcome measures will be tested as in the first year. The other part of the study recruited 46 patients with mild cognitive impairment, who were randomized into either a four-week isokinetic or isotonic training program. All cases were evaluated by isokinetic peak torque, 36-item Short Form Survey (SF-36), Mini-Mental State Examination (MMSE), Barthel Index, geriatric depression scale (GDS-15), and Timed Up and Go test (TUG test) before and after each kind of training.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 107
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Isotonic training Isotonic training Isotonic training Isokinetic training Isokinetic trinaing Isokinetic training Strength training Strength training Muscle strength training programs Aerobic training Aerobic training Aerobic training programs
- Primary Outcome Measures
Name Time Method Geriatric Depression Scale 4 weeks To evaluate patient's depression status, range from 0-15, higher values represent a worse outcome
SF-36 4 weeks consists of 36 questions categorized into 8 subdomains, including physical functioning, role limitations due to physical health, pain, general health condition, vitality, social functioning, role limitations due to emotional problems, and emotional well-being.
Mini-mental state examination 4 weeks To evaluate cognitive function, range from 0-30, higher values represent a better outcome
Montreal Cognitive Assessment 4 weeks To evaluate cognitive function, range from 0-30, higher values represent a better outcome
Barthel index 4 weeks To evaluate function of activities of daily living, range from 0-100, higher values represent a better outcome
Timed up and go test 4 weeks Measure the time taken by a patient to stand up from a chair, walk three meters, return, and sit back on the chair
- Secondary Outcome Measures
Name Time Method Concentration of serum brain derived neurotrophic factor (BDNF) 4 weeks Increasing BDNF level is related to preventing neurodegeneration.
Concentration of plasma insulin-like growth factor-1 (IGF-1) 4 weeks Lower plasma level of IGF-1 is associated with an increased risk of developing Alzheimer's dementia, and higher levels of it may protect against neurodegeneration.
Concentration of plasmamonocyte chemotactic protein-1 (MCP-1) 4 weeks The elevation of MCP-1 concentration usually means the progression of systemic inflammation.
Trial Locations
- Locations (1)
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan