ACTRN12612000846820已完成未知
Effects of small intestinal L-phenylalanine infusions on antropyloroduodenal motility, gut hormone release, blood glucose control and energy intake in healthy, normal weight subjects.
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 15 Years 至 50 Years（—）
- 性别
- All
入选标准
- •Male and female (BMI 18 to 25 kg/m2) subjects, aged between 18 to 50 years, will be included in the study. All subjects will be required to be weight-stable (ie less than 5 % fluctuation in their body weight) at study entry, as determined by their self-reported weight in the preceding 3 months, and will be required to maintain their normal physical activity over the course of the study.
排除标准
- •Significant gastrointestinal symptoms, disease or surgery, use of prescribed or non-prescribed medications (including vitamins and herbal supplements) which may affect energy metabolism, gastrointestinal function, body weight or appetite (eg domperidone, orlistat, green tea extracts, Astragalus, St Johns Wort etc.) Lactose intolerance/other food allergy, diabetes mellitus, as defined by fasting glucose higher than 6.9 mmol/l and/or glycated haemoglobin higher than 6.2 %, epilepsy, cardiovascular or respiratory diseases, current intake of more than 2 standard drinks on more than 5 days per week, current smokers of cigarettes/cigars/marijuana, restrained eaters (score more than 12 on the three factor eating questionnaire), vegetarians, in female subjects, pregnancy or lactation. Phenylketonuria (PKU) ie missing the enzyme phenylalanine hydroxylase, which is needed to break down phenylalanine.
研究者
相似试验
尚未招募
不适用
Effects of short term increase of phenylalanine levels on neuropsychological functions and well-being in adults with phenylketonuria: the *diet for life* study1002742410021605PKUphenylketonuriaNL-OMON30968Academisch Medisch Centrum20
已完成
不适用
Effects of intragastric administration of L-phenylalanine on gastric emptying, gut hormone release, blood glucose and energy intake in healthy, normal weight subjects.Type 2 diabetesHealthy human gastrointestinal physiologyDiet and Nutrition - ObesityOral and Gastrointestinal - Normal oral and gastrointestinal development and functionMetabolic and Endocrine - DiabetesObesityACTRN12616001595404Christine Feinle-Bisset32
招募中
不适用
The Diet for Life study.NL-OMON23483AMC20
已完成
不适用
The effects of small intestinal L-tryptophan infusions on gut motility, gut hormone release, blood glucose control and energy intake in humans.Healthy human physiologyDiet and Nutrition - ObesityOral and Gastrointestinal - Normal oral and gastrointestinal development and functionObesityACTRN12612000811808Christine Feinle-Bisset20
招募中
不适用
Effects of intragastric administration of L-amino acids on gastric emptying, gut hormone release, blood glucose and energy intake in healthy, normal weight and overweight or obese type 2 diabetic patients.Healthy Human Gastrointestinal PhysiologyDiet and Nutrition - ObesityOral and Gastrointestinal - Normal oral and gastrointestinal development and functionMetabolic and Endocrine - DiabetesType 2 DiabetesObesityACTRN12614000837628Christine Feinle-Bisset320