A randomised study to compare the effects of i.v Esmolol vs i.v Labetalol in attenuating hemodynamic response during extubation in Department of Anesthesia, S.M.S Medical College Jaipur
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Heart rate
研究概览
简要总结
Background: During extubation, the process of removing a breathing tube after surgery, patients often experience significant hemodynamic responses such as increased heart rate and blood pressure due to airway stimulation. These responses can cause complications, especially in patients with cardiovascular risks. Beta-blockers like esmolol and labetalol are commonly used to manage these responses due to their cardio-protective properties. However, there is limited evidence comparing their effectiveness and safety during extubation.
Purpose: The study aims to compare the efficacy of intravenous esmolol and labetalol in attenuating the hemodynamic responses during extubation. The goal is to determine which drug provides better control of heart rate and blood pressure with minimal side effects, ensuring a safer extubation process for patients undergoing general anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients giving consent for general anaesthesia 2.Adult patients of either sex.
排除标准
- •1.Patients posted for emergency surgery 2.Physical status ASA Class III or more 3.Patients having any significant systemic disorder 4.Patients having comorbid diseases.
结局指标
主要结局
Heart rate
时间窗: baseline, after giving reversal, at the end of drug administration, 1 min after administration, at the time of extubation, after extubation
次要结局
- systolic bp, diastolic bp, mean arterial bp(baseline, after giving reversal, at the end of drug administration, 1 min after administration, at the time of extubation, after extubation)
研究者
Dr Shriphal Meena
Sawai Man Singh Medical College and Hospital, Jaipur