Comparison of effects of post extubation non invasive ventilation with passive humidification and high flow nasal canula in patients with high risk of extubation failure
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Reintubation within 48 hours of extubation
研究概览
简要总结
Post-extubation failure is defined as the need for reintubation within 48hrs of planned extubation.
Post extubation respiratory failure occurs in 10% to 20% of patients with planned extubation and results in reintubation
Re-intubation due to post-extubation failure is associated with poor outcomes which includes,
An increased incidence of ventilator-associated pneumonia
Increased mortality rates
longer intensive care unit (ICU) and
hospital stays.
NIV is recommended in patients whom clinicians would normally consider NIV is beneficial (i.e. hypercapnic and obese patients)
A high flow nasal canula (HFNC), a relatively recent oxygenation device, offers sufficient warm humidity in addition to a high flow of oxygenation and PEEP.
Due to the high gas flow rate, HFNC can create a persistently positive airway pressure effect in the airway, which may have a beneficial physiologic effect.
It is not clear which subgroups of patients could benefit with HFNC or NIV
A recent study shows NIV with active humidification was superior to HFNC for preventing re-intubation in patients with high-risk of extubation failure.
No study has been made to see the effects of post extubation NIV with passive humidification in comparison with HFNC in patients with post extubation failure.
Hence this study has been designed to compare NIV with passive humidification to HFNC in patients with postextubation failure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •critically ill patients who are at high risk of extubation failure.
排除标准
- •Patient who dont give consent for part of study , Do not resuscitate orders, Tracheostomised patients, Age less than 18years, Accidental or self extubation , Do not reintubate orders Contraindication for NIV therapy.
结局指标
主要结局
Reintubation within 48 hours of extubation
时间窗: 48hrs
次要结局
- Postextubation respiratory failure within 7 days of extubation(Respiratory infection(ventilator associated pneumonia ))
研究者
Nimisha patil
Era lucknow medical college and hospital