Lactated Ringers vs Normal Saline in Patients With Acute Pancreatitis: A Bias-Adjusted Meta-analysis

Recruiting

• Conditions: Acute Pancreatitis

• Registration Number: NCT05638555
• Lead Sponsor: Qatar University

Brief Summary

This study aims to compare NS and LR in terms of outcomes in patients with acute pancreatitis while addressing the current methodological issues with available meta-analyses on the topic. Such comparison combined with bias adjustment will assist with identifying the optimal fluid rehydration therapy in acute pancreatitis, since most of the available data is conflicted around the topic. A database search will be conducted to identify studies comparing normal saline and ringer's lactate. Existing meta-analyses will be assessed. The results will be discussed in the light of their strengths and limitations and then any deficiencies will be addressed through a new synthesis as a final step of this umbrella review. The primary outcome will be SIRS at 24 hours. OR and 95% confidence intervals will be generated using the quality effects model. Heterogeneity will be evaluated using the I2 statistic. Publication bias will be assessed using the Doi Plot.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-11-13
• Study First Submitted QC: 2022-12-02
• Study First Posted: 2022-12-06
• Study Start: 2023-08-15
• Status Verified: 2023-10
• Last Update Submitted: 2023-10-28
• Last Update Posted: 2023-10-31
• Primary Completion: 2024-04-01
• Study Completion: 2024-06-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• RCTs and observational studies that compared NS vs LR in AP patients.
• Studies reviewed must report data as effect estimates or provide raw data sufficient to calculate effect estimates.

Exclusion Criteria

• Studies involving animal studies, pediatric patient populations, and cell lines will be excluded.

All studies will be reviewed in full form by each author to determine eligibility. In case of disagreement, determination of inclusion will be reached via consensus.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Systemic inflammatory response syndrome (SIRS)	at 24 hours	SIRS is defined as two out of the following four criteria: a) Temperature\<36˚C (96.8˚F) or \>38˚C (100.4˚F) b) Heart rate\>90/min c) Respiratory rate\>20/min d) WBC(\<4000/mm3) (\>12,000/mm3) or 10% bands.

Trial Locations

Locations (1)

Suhail Doi; 🇶🇦 Doha, Qatar