Effect of Intravenous Tranexamic Acid in Reducing in Spinal Surgeries

Phase 3

Conditions: Condition 1: Far lateral lumbar disc herniation. Condition 2: Lumbar spinal stenosis. Condition 3: Spondylolisthesis. Condition 4: Scoliosis. Condition 5: Lordosis. Condition 6: Extensive fracture of the lumbar vertebrae.

Registration Number: IRCT20230519058227N1

Lead Sponsor: Karaj University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 84

Inclusion Criteria

A patient with far lateral lumbar disc herniation who requires instrumentation.
A patient with lumbar spinal stenosis who requires instrumentation.
A patient with Spondylolisthesis who requires instrumentation.
A patient with Scoliosis who requires instrumentation.
A patient with Lordosis who requires instrumentation.
A patient has a extensive fracture of the lumbar vertebrae who requires instrumentation.

Exclusion Criteria

Patient dissatisfaction
Patients taking Anticoagulant Drugs.
People with Congenital Coagulopathy.
Patients who have a history of any type of Cerebral Hemorrhage such as SAH, ICH, SDH, EDH, IVH.
Patients who have a history of Anaphylactic Reaction.
Women who are pregnant.
Patients who have a history of DVT and PTE.
Patients who have a history of Chronic Renal Failure (Cr-baseline > 1.36 mg/dl).
Patients with Chronic Liver Disease.
Patients who have Platelets < 100,000 mm3.
Patients who have INR > 1.5.
Patients who have PT > 14.
Patients who have PTT > 35.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bleeding volume during operation. Timepoint: During operation. Method of measurement: By collecting the amount of blood in the suction and subtracting its amount from the amount of serum that was used in the washing place (the amount of serum used is noted) and counting the number of blood cells approximately.;The volume of blood collected daily in the hemovac drain after the operation. Timepoint: After installing the Hamovac drain on a daily basis. Method of measurement: The amount of blood collected in the Hemovac drain is charted daily in coordination with the surgeon.

Secondary Outcome Measures