Dopaminergic functioning and reactivity to social stress in the daily life of young hard of hearing individuals.

Conditions: 10019243
10039628
schizophrenia psychosis

Registration Number: NL-OMON37943

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

Participated in study 08-248 / NL24257.018.08.
(healthy individuals aged 18-30, either normal hearing or more than 60dB hearing loss bilaterally, Dutch etnicity, completed primary school)

Exclusion Criteria

1. Current or past psychotic disorder
2. Psychotic disorder in parents or full siblings
3. History of meningitis.
4. Neurological disorder (e.g., epilepsy) or evidence of brain damage.
5. Current use of drugs known to interfere with DA release. Current or past use of antipsychotic drugs.
6. Attended bilingual primary or secondary school. (Dutch Sign Language / Dutch)
7. Control subjects: major impairments which may lead to social exclusion (e.g.,
dependence on wheel chair).
8. Subjects with HI: no other major impairments than HI leading to social exclusion.
At discretion of researcher.
9. Clinical diagnosis of Attention Deficit Hyperactivity Disorder (ADHD).

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Relationship between hearing impairment and reactivity (changes in affect and<br /><br>psychotic symptoms) to self-reported stress in daily life, assessed using the<br /><br>Experience Sampling Method (ESM)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Association between dopamine release and stress reactivity.<br /><br><br /><br>Theory of mind as a mediator between hearing impairment and stress/DA release<br /><br>outcomes<br /><br><br /><br>Group level differences in reactivity to other forms of (event related,<br /><br>activity) stress.</p><br>