A Prospective observational trial to assess if thromboelastography (TEG) can be used to predict blood culture results in clinically septic patients.

Not Applicable

Completed

• Conditions: Sepsis; coagulation; Infection - Other infectious diseases; Blood - Clotting disorders

• Registration Number: ACTRN12616001152415
• Lead Sponsor: Intensive Care Unit, Logan Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-08-24
• Study Completion: 2018-04-05
• Last Update Posted: 19 April 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Patients admitted to ICU who;
- are aged >18 years
- Have SIRS; 2 of the following criteria on admission;
- Temperature >38 or <36
- Pulse rate >90/minute
- Respiratory rate >20/minute or PaCo2 <32mmHg
- White cell count >12 or >10% immature bands
- Clinical diagnosis of sepsis

Exclusion Criteria

- Pre-existing diagnosis of a coagulation disorder
- On anticoagulant treatment eg heparin infusion, treatment dose low-molecular weight heparin, warfarin or oral anticoagulants

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine whether the TEG results from patients who are admitted to the ICU with clinically diagnosed sepsis (using SIRS criteria and clinical suspicion of an infectious source) are correlated to obtaining a positive blood culture result.[The blood samples will be taken on admission to ICU.]

Secondary Outcome Measures

Name	Time	Method
To determine if standard laboratory coagulation studies correlate with the TEG changes in culture positive sepsis[Results from the routine blood tests taken on admission to ICU will be compared to blood samples taken for TEG at admission ];To determine if TEG changes on discharge from the ICU have resolved with clinical improvement[Blood sample will be taken on discharge from ICU];Diagnosis on admission to hospital, by review of hospital records[At time of admissin];Diagnosis on admission to ICU, by review of hospital records[At time of admission ];Length of stay in the ICU, by review of hospital records[At time of ICU discharge];Source of sepsis, by review of hospital records[At time of ICU discharge];Use of vasoactive drugs, by review of hospital records[At time of ICU discharge];Hospital mortality, by review of hospital records[At time of hospital discharge or death]