A Prospective Observational Study of Patients Suffering From Prolonged Critical Illness Treated by Patient Centered Multidisciplinary Teams at a Specialized Unit: Patient Characteristics, Treatment and Follow-up Results
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Critical Illness
- Sponsor
- Remeo AB
- Enrollment
- 250
- Locations
- 1
- Primary Endpoint
- Change in mechanical ventilation status
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
This prospective observational study aims to describe the outcome for patients with persistent or chronic critical illness treated at Remeo, a clinic specialized for patients in need of prolonged intensive care and intensive care rehabilitation in Sweden. Patients' disease characteristics and the treatment in multidisciplinary patient centered teams for intensive care, weaning from mechanical ventilation and simultaneous rehabilitation will be described. Patients will be followed one year after discharge to document health related quality of life, physical function, frailty, mental illness and used health care resources.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Admission to unit (Remeo, Stockholm, Sweden) Treated for prolonged critical illness
Exclusion Criteria
- •Treated less than 48 hours at unit (Remeo, Stockholm, Sweden)
Outcomes
Primary Outcomes
Change in mechanical ventilation status
Time Frame: Assessed at admittance and immediately after discharge from unit
Time (Days) from admittance to unit until weaned from mechanical ventilation
In-patient mortality and mortality
Time Frame: Assessed immediately after discharge from unit
Mortality during care at unit
Mortality during 12 months follow-up after discharge
Time Frame: Assessed 12 months after discharge
Mortality during 12 months follow-up after discharge
Health related quality of Life assessed by the Rand 36-Item Health Survey (RAND36)
Time Frame: 12 months after discharge from unit
RAND36 (scale 0-100, higher value better) questionnaire
Health related quality of Life assessed by EuroQoL 5-dimension 5-level (EQ-5D-5L)
Time Frame: 12 months after discharge from unit
EQ-5D-5L questionnaire
Change in tracheostomy status
Time Frame: Assessed at admittance and immediately after discharge from unit
Time (Days) from admittance to unit until decannulation
Independence in activities of daily living assessed by Katz Index of Independence in Activities of Daily Living (Katz ADL)
Time Frame: 12 months after discharge from unit
Katz ADL (scale 0-6, higher value better)
Secondary Outcomes
- Symptoms of depression as assessed by the Patient Health Questionnaire-9 (PHQ-9)(12 months after discharge from unit)
- Symptoms of generalized anxiety as assessed by the General anxiety disorder 7 (GAD-7) questionnaire(12 months after discharge from unit)
- Swallowing function and possibility of oral intake(At at 12 months after discharge from unit)
- Frailty as assessed by the Clinical frailty scale (CFS)(At 12 months after discharge from unit)
- Physical status as assessed by the 6 minutes walk test(12 months after discharge from unit)
- Physical status as assessed by the Chelsea Critical Care Physical Assessment tool (CPAx).(12 months after discharge from unit)
- Cognitive status as assessed by the Montreal cognitive assessment (MoCa) test(Immediately before discharge from unit)
- Inflammatory status relative to outcome(Through study completion, an average of 14 months)