Effect of Intravenous Dextrose on PONV in Patients Undergoing Gynecological Laparoscopy

Not Applicable

Recruiting

• Conditions: Postoperative Nausea and Vomiting
• Interventions: Other: lactated ringers; Other: 5% glucose

• Registration Number: NCT05932160
• Lead Sponsor: Weifang Medical University

Brief Summary

This study is to explore the relationship between intravenous infusion of dextrose during emergence from anesthesia and the incidence of PONV in patients undergoing gynecology laparoscopy (GL).

Detailed Description

Not available

Study Timeline

• Study Start: 2023-06-01
• Study First Submitted: 2023-06-06
• Study First Submitted QC: 2023-06-26
• Study First Posted: 2023-07-06
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-02
• Last Update Posted: 2023-11-07
• Primary Completion: 2023-12-30
• Study Completion: 2023-12-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 108

Inclusion Criteria

1. ASA I or II;
2. Performing gynecologic laparoscopic procedures under general anesthesia;

Exclusion Criteria

1. age <18 or >75
2. severe hypertension,diabetes mellitus, significant hepatic or renal disease
3. inability to follow protocol
4. refusal to participant

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	lactated ringers	Patients in the control group were infused intravenously with ringer lactate solution (400 ml/h) in the PACU. The study outcomes were collected at three assessment periods, 0-0.5 h, 0.5-6 h, 6-24 h, after anesthesia by an independent investigator.
Experimental group	5% glucose	Patients in the experimental group were infused intravenously with 5% dextrose (400 ml/h) in the PACU. The study outcomes were collected at three assessment periods, 0-0.5 h, 0.5-6 h, 6-24 h, after anesthesia by an independent investigator.

Primary Outcome Measures

Name	Time	Method
Postoperative nausea and vomiting	Measured at 24 hours postoperatively.	The severity and incidence of PONV at 24 hours postoperatively.

Secondary Outcome Measures

Name	Time	Method
Recovery time of PACU	Approximately 24 hours after surgery.	Record PACU recovery time in hours. The criteria for discharge from PACU was the achievement of a modified Aldrete score ≥ 9.
Consumption of postoperative rescue antiemetic	Approximately 24 hours after surgery.	Record the type and dosage of postoperative rescue antiemetic within 24 hours after surgery.
Consumption of postoperative analgesic	Approximately 24 hours after surgery.	Record the type and dosage of postoperative analgesic within 24 hours after surgery.
Postoperative pain response	Measured at 24 hours postoperatively.	The Visual Analog Score was used to assess pain response at 24 hours postoperatively.; The score ranges from 0 (pain free or no pain) to 10 (worst pain).

Trial Locations

Locations (1)

Jiang Liu; 🇨🇳 Weifang, Shandong, China