Effect of Intravenous 5% Dextrose Infusion During Recovery from Anesthesia on the Quality of Early Postoperative Recovery in Patients Undergoing Painless Gastrointestinal Endoscopy

Not Applicable

Completed

• Conditions: Insulin Resistance; Postoperative Nausea and Vomiting; Quality of Recovery; Dizzyness
• Interventions: Other: 5% glucose; Other: 0.9% Normal Saline

• Registration Number: NCT06319144
• Lead Sponsor: Weifang Medical University

Brief Summary

The aim of this study was to determine the effect of intravenous infusion of 5% dextrose injection during the recovery period of anesthesia for painless gastroenteroscopy on the patient's blood glucose level, incidence of hypoglycemia and time of awakening from anesthesia, postoperative vertigo, postoperative nausea and vomiting, and quality of recovery in the early postoperative period.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-03-12
• Study First Submitted QC: 2024-03-12
• Study Start: 2024-03-15
• Study First Posted: 2024-03-19
• Primary Completion: 2024-06-20
• Study Completion: 2024-06-22
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-11
• Last Update Posted: 2025-03-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

1. patients who meet the indications for painless gastrointestinal endoscopy and are aged 18 to 79 years.
2. The patient or his/her guardian or immediate family members gave informed consent;
3. American Society of Anesthesiology (ASA) anesthesia risk classification ≤ grade III.

Exclusion Criteria

1. Patients with contraindications to sedation/anesthesia for gastrointestinal endoscopy: e.g., severe hepatic and renal dysfunction, cardiac insufficiency;
2. Patients receiving chemotherapy and opioid treatment; patients with a history of sleep apnea hypoventilation syndrome;
3. Intravenous nutritional support within 8 hours prior to the examination;
4. Patients diagnosed with type I or type II diabetes.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Experimental group	5% glucose	Patients in the experimental group were infused intravenously with 5% dextrose (500 ml/h) in the PACU. The study outcomes were collected at three assessment periods, 0-0.5 h, 0.5-6 h, 6-24 h, after anesthesia by an independent investigator.
Control group	0.9% Normal Saline	Patients in the control group were infused intravenously with 0.9% Normal Saline (500 ml/h) in the PACU. The study outcomes were collected at three assessment periods, 0-0.5 h, 0.5-6 h, 6-24 h, after anesthesia by an independent investigator.

Primary Outcome Measures

Name	Time	Method
Preoperative blood glucose 30min	Measurements taken 0.5 hours Preoperative.	A fingertip blood glucose concentration of \<3.9 mmol/L was used as a diagnostic criterion for hypoglycemia. Severity and incidence of hypoglycemia at 0.5 hours Preoperative.
Postoperative blood glucose 2h	Measured at 2 hours postoperatively.	A fingertip blood glucose concentration of \<3.9 mmol/L was used as a diagnostic criterion for hypoglycemia. Severity and incidence of hypoglycemia at 2 hours postoperatively.
Dizziness level	Measured at 0.5 hours postoperatively.	The visual analogue scale (VAS) was used to assess the degree of postoperative dizziness in patients undergoing painless gastroenteroscopy.
Postoperative nausea and vomiting	Measured at 2 hours postoperatively.	The Index of Nausea and Vomiting and Retching (INVR) was used in this study. The scale consists of 8 items with 3 dimensions, which can quantify the number of occurrences, duration and severity of symptoms. The scale is scored using the Likert method, with a total of 32 points on a 5-point scale ranging from 0 to 4. The higher the score, the more severe the symptoms of nausea, vomiting, and dry heaving (entries 1, 6, and 7 are reverse scored). According to the score, nausea, vomiting and dry heaving symptoms can be categorized into five grades: 0, I, II, III and IV, and grade ≥I means that the symptom occurs. The severity and incidence of PONV at 0.5 hours postoperatively.

Secondary Outcome Measures

Name	Time	Method
Anesthesia awakening time	Approximately 30min after surgery	The clinical routine defines the time of awakening from anesthesia as the time between the cessation of anesthesia administration and the opening of the patient's eyes on call.
Quality of postoperative recovery (QoR40)	Approximately 24hours after surgery	The QoR-40 scale provides a true and valid reflection of the impact of various factors on the quality of postoperative recovery.

Trial Locations

Locations (1)

Lin Cheng; 🇨🇳 Weifang, Shandong, China