TMS for Complex Regional Pain Syndrome

Not Applicable

Recruiting

• Conditions: Complex Regional Pain Syndromes

• Registration Number: NCT03137472
• Lead Sponsor: Stanford University

Brief Summary

The aim of the current study is to assess the efficacy of TMS in the treatment of Complex Regional Pain Syndrome (CRPS). It is hypothesized that participants who receive TMS (Group 1) relative to sham treatment (Group 2) once daily for two days will demonstrate a greater improvement in CRPS-related pain and other associated symptomology (i.e., cognitive, emotional and physical) compared to baseline. Participants will be followed until they reach their baseline for two consecutive weeks to assess safety and duration of symptom alleviation.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-04-24
• Study First Submitted: 2017-04-28
• Study First Submitted QC: 2017-04-28
• Study First Posted: 2017-05-02
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-12
• Last Update Posted: 2025-05-13
• Primary Completion: 2026-06-29
• Study Completion: 2026-06-29

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Age 18-70
• Diagnosis of CRPS (complex regional pain syndrome) for at least 3 months
• Average pain level reported on Numerical Rating Scale meets entry criteria
• Ability to perform the experimental task and procedures.

Exclusion Criteria

• MRI contraindication (metal implants or devices, claustrophobia)
• TMS Contraindication (eg metal implant or devices near the site of stimulation)
• History of epilepsy
• History of a psychological or psychiatric disorder that would interfere with study procedures, at the discretion of the researcher.
• Neurologic illness that would interfere with brain integrity
• Current medical condition or medication use that would interfere with study procedures or data integrity, at the discretion of the researcher.
• Currently pregnant or planning to become pregnant.
• On going legal action or disability claim.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in Pain	1 week follow-up compared to baseline	Decrease in CRPS-related Pain Ratings
Duration of Pain Relief	Duration from last treatment until pain returns - up to an estimate of 6 months	Duration of decreased CRPS-related pain ratings, measured as a length of time until pain returns for two consecutive weeks

Secondary Outcome Measures

Name	Time	Method
Change in Pain-related Symptomology	Duration from last treatment until pain returns - up to an estimate of 6 months	Decreases in Pain-related Symptomology (i.e., cognitive, emotional and physical)

Trial Locations

Locations (1)

Stanford Pain Management Center; 🇺🇸 Redwood City, California, United States