Functional MRI of Relaxation Response Training in Adults With Attention-Deficit/Hyperactivity Disorder

Not Applicable

Completed

• Conditions: ADHD
• Interventions: Behavioral: Meditation/Relaxation Response Training

• Registration Number: NCT01404273
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

This research study is being done to examine how meditation and the relaxation response (RR) may change brain activity in attention-deficit/hyperactivity disorder (ADHD).

Detailed Description

Not available

Study Timeline

• Study Start: 2009-09
• Study First Submitted: 2011-07-25
• Study First Submitted QC: 2011-07-26
• Study First Posted: 2011-07-28
• Primary Completion: 2011-09
• Study Completion: 2011-09
• Status Verified: 2013-07
• Last Update Submitted: 2013-07-29
• Last Update Posted: 2013-07-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

1. Male or female adults (ages 18 - 49).
2. Patients with the diagnosis of Attention Deficit Hyperactivity Disorder (ADHD), by the Diagnostic and Statistics Manual of Mental Disorders (DSM-IV), as manifested in clinical evaluation and confirmed by structured interview.

Exclusion Criteria

1. Any current, non-ADHD Axis I psychiatric conditions
2. Baseline Beck Depression Inventory (BDI) > 19.
3. Any clinically significant chronic medical condition.
4. Mental retardation
5. Organic brain disorders
6. Seizures or tics.
7. Pregnant or nursing females.
8. Clinically unstable psychiatric conditions (suicidal behaviors, psychosis).
9. Current or recent (within the past 2 years) substance abuse or dependence.
10. Patients currently or recently (within past 1 month) on psychotropic medication.
11. Subjects with current or prior adequate psychopharmacologic treatment for ADHD.
12. Regular practice of an Relaxation Response-inducing technique within the past year
13. History of claustrophobia or any of the standard contraindications to magnetic resonance imaging (MRI) scanning(metal objects within body).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Meditation/Relaxation Response Training	Meditation/Relaxation Response Training	-

Primary Outcome Measures

Name	Time	Method
Change in functional magnetic resonance imaging (fMRI) activation from baseline after a 6-week intervention	2 sessions, 2 hours each to be conducted before and after the 6-week intervention	functional magnetic resonance imaging (fMRI) activation in dorsal anterior medial cingulate cortex (daMCC) \& dorsolateral prefrontal cortex (DLPFC) during multi-source interference task (MSIT)

Trial Locations

Locations (1)

Benson-Henry Institute, 151 Merrimac St, 4th Floor; 🇺🇸 Boston, Massachusetts, United States