NCT02880111终止不适用
Comparison of Rates DMBT1 ( Glycoprotein) in Sputum of CF Patients Colonized Patients Between Chronic and Non-chronic Patients Colonized With Pseudomonas Aeruginosa
University Hospital, Lille1 个研究点 分布在 1 个国家目标入组 1 人开始时间: 2016年3月23日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 1
- 试验地点
- 1
- 主要终点
- measure glycoprotein-like DMBT1 by Elisa
研究概览
简要总结
Rates of DMBT1 (Glycoprotein like) in Sputum of CF Patients with or without may be different according to their Pseudomonas Aeruginosa chronic colonization status. The aim of this study is to compare rates of DMBT1 (Glycoprotein like) in Sputum of CF patients with or without a Pseudomonas Aeruginosa chronic colonization.
详细描述
Rates of DMBT1 (Deleted in Malignant Brain Tumor 1) will be compared between 2 groups of 30 CF patients : group 1 : with Pseudomonas Aeruginosa chronic colonization and group 2 30 CF patients without Pseudomonas Aeruginosa chronic colonization.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •CF patient 6 years
- •Availability of sputum
- •Signed Informed consent
排除标准
- •Cardiac insufficiency
- •Anti-inflammatory drugs on going
- •Oral corticosteroid therapy
- •Inhaled corticosteroids during the two weeks before inclusion,
- •Patient awaiting lung transplantation
- •Patient with a past history of heart/lung transplantation
- •Patient with a sputum examination positive for : atypical mycobacteria, Burkholderia cepacia, Stenotrophomonas maltophilia,
- •Patient chronically colonized with multiresistant Pseudomonas aeruginosa
- •Orkambi© or Kalydeco© therapy
- •Change of the CF treatment during the last 4 weeks +/- 2 days before inclusion : corticosteroid, pancreatic extracts, antisecretory drugs...
结局指标
主要结局
measure glycoprotein-like DMBT1 by Elisa
时间窗: at 1 months
DMBT1 in mg DMBT1 / mg of total protein measured by BCA (BiCinchoninic acid Assay) present in each sputum
次要结局
- measure MUC5B by Elisa(at 1 months)
研究者
研究点 (1)
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