Stress-Coping and Cortisol Analysis in Patients with Non-Syndromic Cleft Lip and Palate: An Explorative Study

• Conditions: Q35-Q37; F43; Cleft lip and cleft palate; Reaction to severe stress, and adjustment disorders

• Registration Number: DRKS00003466
• Lead Sponsor: Klinik für Mund-, Kiefer- und Gesichtschirurgie, Universitätsklinikum Schleswig-Holstein

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2011-03-30
• Study Start: 2012-01-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Patients: unilateral cleft lip and palate
Controls: healthy control person

Exclusion Criteria

acute infections, drug or alcohol abusus, mental illness

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Seven saliva samples were collected to determine the cortisol level at different time points. The samples were taken at following time points. 2 minutes before the Trier Social Stress Test (TSST). 1, 10, 20, 30, 45 and 60 minutes after the TSST. Cortisol concentration was analyzed by ultra performance liquid chromatography-tandem mass spectrometry.

Secondary Outcome Measures

Name	Time	Method
The evaluation of stress-coping was performed by Stressverarbeitungsfragebogen (SVF 120) first described by Jahnke. Each participant has to complete the questionnaire after the TSST.