ISRCTN84990302已完成未知
Cortisol hyper-reactivity to stress - a putative biomarker for major depressive disorder
Cambridgeshire and Peterborough NHS Foundation Trust (UK)0 个研究点目标入组 228 人开始时间: 2010年5月12日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 228
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
入选标准
- •1. Aged 16 - 21 years old
- •2. Male and female
- •3. Recruited from Roots study
排除标准
- •1. Take regular steroid medication (oral or inhaled) or take hormonal contraceptives containing oestrogens (combined pill, injection, implant or patch)
- •2. Hypertension requiring regular treatment
- •3. Systolic blood pressure above 140 mmHg or resting pulse over 100 mmHg at the start of the study
- •4. Current respiratory disease, e.g., asthma
- •5. A personal or family history (parent or sibling) of panic disorder
- •6. Significant claustrophobia
- •7. Smoke daily; no smoking on day of assessment
- •8. Migraine within the last year
- •9. Current heart disease
- •10. Females will be excluded if they are or think they might be pregnant, are lactating, or their menstrual cycle has not returned to being regular after pregnancy
- •11. At least one biological grandparent known to be non-white European
- •12. At least one of the following psychiatric disorders at time of interview: anxiety disorder, OCD, oppositional defiant disorder, PTSD, conduct disorder, bipolar disorder
- •13. Alcohol or illicit drug use on the day of or the day before research assessment
- •14. Caffeine use since breakfast on the day of research assessment
- •15. Consume large amounts of caffeinated drinks on a regular basis (greater than six cups of coffee per day or drinks containing methylxanthines such as Pepsi or red bull)
- •16. Current severe cold or flu
- •17. Vigorous exercise for 2 hours before testing
- •Additional group-specific criteria:
- •18. Never-depressed participants:
- •18.1. No lifetime history of major depressive disorder
- •18.2. No lifetime history of at least one of the following psychiatric disorders: anxiety disorder, OCD, oppositional defiant disorder, PTSD, conduct disorder, bipolar disorder, ADHD
- •19. Recovered-depressed:
- •19.1. At least one past episode of major depressive disorder
- •19.2. At least 8 weeks of having fewer than two depressive symptoms since last episode
- •19.3. Not currently taking antidepressants
- •19.4. No lifetime history of ADHD, autism, conduct disorder with onset before age 11
研究者
相似试验
已完成
不适用
Cortisol Levels in AcUte Stress momentsinvloed van stress op hormoonspiegels in bloed (cortisol). Het betreft een onderzoek bij gezonde personen waarvan niet verwacht wordt dat ze een aandoening hebben.StressanxietyNL-OMON46369Zuyderland Medisch Centrum100
招募中
不适用
Relationship of Serum Cortisol on Stress, Anxiety and Impact of Yoga on Stress for Infertile Women attending Tertiary Care Centre.CTRI/2020/12/029650Medical Education and Research Trust Karnataka
招募中
不适用
The stress hormone COrtisol and the development of MEtabolic Syndrome and Cardiovascular DIseases Unravelling the cause(s) of hypercortisolism in obesity: Investigating the influence of the liver, gut and immune systemObesityNL-OMON54740Erasmus MC, Universitair Medisch Centrum Rotterdam200
已完成
不适用
Relationship between stress markers in smokers and nonsmokers with chronic periodontal diseaseCTRI/2017/10/010158nil75
已完成
不适用
Stress-Coping and Cortisol Analysis in Patients with Non-Syndromic Cleft Lip and Palate: An Explorative StudyQ35-Q37F43Cleft lip and cleft palateReaction to severe stress, and adjustment disordersDRKS00003466Klinik für Mund-, Kiefer- und Gesichtschirurgie, Universitätsklinikum Schleswig-Holstein30