Cortisol reactivity as a biomarker for depressio

Not Applicable

Completed

• Conditions: Topic: Mental Health Research Network; Subtopic: Depression, Stress-related and somatoform; Disease: Depression, Stress-related and somatoform disorders; Mental and Behavioural Disorders; Depressive episode

• Registration Number: ISRCTN84990302
• Lead Sponsor: Cambridgeshire and Peterborough NHS Foundation Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-05-12
• Last Update Posted: 8 May 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 228

Inclusion Criteria

1. Aged 16 - 21 years old
2. Male and female
3. Recruited from Roots study

Exclusion Criteria

1. Take regular steroid medication (oral or inhaled) or take hormonal contraceptives containing oestrogens (combined pill, injection, implant or patch)
2. Hypertension requiring regular treatment
3. Systolic blood pressure above 140 mmHg or resting pulse over 100 mmHg at the start of the study
4. Current respiratory disease, e.g., asthma
5. A personal or family history (parent or sibling) of panic disorder
6. Significant claustrophobia
7. Smoke daily; no smoking on day of assessment
8. Migraine within the last year
9. Current heart disease
10. Females will be excluded if they are or think they might be pregnant, are lactating, or their menstrual cycle has not returned to being regular after pregnancy
11. At least one biological grandparent known to be non-white European
12. At least one of the following psychiatric disorders at time of interview: anxiety disorder, OCD, oppositional defiant disorder, PTSD, conduct disorder, bipolar disorder
13. Alcohol or illicit drug use on the day of or the day before research assessment
14. Caffeine use since breakfast on the day of research assessment
15. Consume large amounts of caffeinated drinks on a regular basis (greater than six cups of coffee per day or drinks containing methylxanthines such as Pepsi or red bull)
16. Current severe cold or flu
17. Vigorous exercise for 2 hours before testing

Additional group-specific criteria:
18. Never-depressed participants:
18.1. No lifetime history of major depressive disorder
18.2. No lifetime history of at least one of the following psychiatric disorders: anxiety disorder, OCD, oppositional defiant disorder, PTSD, conduct disorder, bipolar disorder, ADHD
19. Recovered-depressed:
19.1. At least one past episode of major depressive disorder
19.2. At least 8 weeks of having fewer than two depressive symptoms since last episode
19.3. Not currently taking antidepressants
19.4. No lifetime history of ADHD, autism, conduct disorder with onset before age 11

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Salivary cortisol area under the curve in the time period after intervention, collected 20 minutes before and immediately before, and 20, 30, 40 and 60 minutes after, the onset of each stress test.

Secondary Outcome Measures

Name	Time	Method
1. Performance on affective go:no go, measured at rest (before first stress test) and 30 minutes after the start of each stress test<br>2. Ratio of negative to positive words correctly recalled, measured at rest (before first stress test) and 25 minutes after the start of each stress test<br>3. Which stress test leads to largest rise in cortisol?