The stress hormone COrtisol and the development of MEtabolic Syndrome and Cardiovascular DIseases Unravelling the cause(s) of hypercortisolism in obesity: Investigating the influence of the liver, gut and immune system
Recruiting
- Conditions
- metabolic syndromeObesity100013531000301810017998
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
Eligibility for bariatric surgery according to the current clinical standards
sufficient scalp hair for analysis
Exclusion Criteria
medication that interferes with the cortisol, the microbiome or the immune
system
abnormal renal function
diseases or conditions leading to hepatic steatosis ( e.g. alcohol, viral
hepatitis, hepatotoxic drugs)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The relation between hepatic steatosis, cortisol status, immune status and gut<br /><br>microbiota in patients with obesity, in association with weight changes<br /><br>(because of bariatric surgery or a CLI)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary Objective(s):<br /><br>- To study the differential weight-reducing treatments (1. Bariatric surgery<br /><br>and 2. Combined lifestyle intervention) on cortisol status, immunological<br /><br>factors, and gut microbioma</p><br>