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临床试验/NCT00788645
NCT00788645已完成早期 1 期

The Use of a Forecasting System for Predicting Exacerbations of COPD: Effect on Symptoms and Hospitalisation and Relevance of Viral Infections

AstraZeneca1 个研究点 分布在 1 个国家目标入组 98 人开始时间: 2008年8月最近更新:
适应症

试验速览

阶段
早期 1 期
状态
已完成
发起方
AstraZeneca
入组人数
98
试验地点
1
主要终点
The incidence and frequency of COPD exacerbations in each of the intervention groups

研究概览

简要总结

People with Chronic Obstructive Pulmonary Disease (COPD) often have periods during the year when their symptoms become worse. These are often due to an infection and are called "exacerbations" by doctors. Exacerbations are more common in the winter and also seem to be related to particular types of weather. As well as forecasting the weather the UK Met Office has developed a system to try to predict when exacerbations are likely to occur. The main purpose of this research study is to find out whether the Met Office forecasting service can predict when exacerbations are more likely to occur and whether the advice given during the predicted higher risk periods leads to fewer patients having an exacerbation or if it reduces the impact of the exacerbation. The study will also assess if there is a link between viral or bacterial infection and breathing problems that occur during the study period. The study will also collect information about possible causes of the breathing problems and what happens to the person afterwards. The results of this study will help us learn more about breathing problems which may lead to new research studies that would aim to improve the care of people with COPD.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
None

入排标准

年龄范围
40 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Current or former smokers with a diagnosis of COPD
  • Having impaired lung function as measured by spirometry

排除标准

  • History of asthma or nasal symptoms caused by hayfever
  • No telephone
  • Inability to record symptoms in an electronic diary (PDA)

结局指标

主要结局

The incidence and frequency of COPD exacerbations in each of the intervention groups

时间窗: December 2008 to March 2009 inclusive

Electronic diary symptoms using the EXACT instrument

时间窗: Daily recording

次要结局

  • Medication usage and hospital admissions(Acutely)
  • Changes in the St Georges Respiratory questionaire(Start and end of study period)
  • Severity and duration of exacerbations assessed using the EXACT instrument(Daily recording)

研究者

发起方
AstraZeneca
申办方类型
Industry

研究点 (1)

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