Relationship Between Gestational Diabetes Mellitus and Inflammatory Adipocytokins in Obese Mothers and Their Newborn at Delivery
- Conditions
- Diabetes, Gestational
- Registration Number
- NCT02905487
- Lead Sponsor
- Centre Hospitalier Universitaire de la Réunion
- Brief Summary
ADIPOGEST study aims at comparing circulating levels of inflammatory adipocytokins and C-reactive protein in obese women and their newborn at delivery whether exposed or not to Gestational Diabetes Mellitus (GDM)
- Detailed Description
ADIPOGEST is a cross sectional study in which mothers are divided into 2 groups : exposed and unexposed to GDM, matched on pregestational BMI, date of delivery and child gender.
Mothers are recruited in the maternity ward of the University Hospital in South of Reunion Island.
It is planned a conveniance sample of 20 mother-child pairs per group.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Pregnant women
- Obese women (BMI : 30 kg/m² or more)
- Aged over 18 years
- With single pregnancy
- With alive newborn at 37 weeks of amenorrhea or more
- With informed consent
Exclusion Criteria
- Smoker
- Treatments by corticoïds or thyroid hormons
- Overt diabetes
- Complicated pregnancy
- Premature delivery threat
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood levels of leptin in mother and her child 2 years Blood levels of C- Reactive Protein in mother and her child 2 years Blood levels of adiponectin in mother and her child 2 years Blood levels of IL-6 in mother and her child 2 years Blood levels of TNF-alpha in mother and her child 2 years
- Secondary Outcome Measures
Name Time Method Blood level of C-peptide in mother 2 years
Trial Locations
- Locations (1)
Centre Universitaire de La Réunion
🇫🇷Saint Pierre, France