Effect of Low Intensity Strength Training Combined With Moderate Blood Flow Restriction on Muscle Vasodilatation and Arterial Stiffness in Elders With Low Gait Velocity.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Anthropometric Assessment
研究概览
简要总结
The purpose of the present study is to evaluate the acute and chronic effect of low intensity strength training with or without moderate blood flow restriction on muscle vasodilation and arterial stiffness in elders with low gait speed. In addition, the responses of prothrombotic factors in blood coagulation, the impact on heart rate and arterial pressure will be assessed.
详细描述
The investigators propose a study of 26 sedentary elders with low speed gait, supervised by the Hospital Israelita Albert Einstein - Vila Mariana ambulatory. This will be an open clinical trial, prospective, single center, randomized and controlled study. It will be divided into two parts: acute and chronic phases. After signing an informed consent, the participants will be separated in two groups:
Group 1. Resistance exercise with low intensity combined with partial blood flow restriction Group 2. Conventional resistance exercise with low intensity
All of participants will be submitted to interventions tests before and after the period of training which are:
- Laboratory Tests: Blood tests
- Plethysmography
- Handgrip
- Quality of life questionaire
- FMD tests
- Vasodilation capacity
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 60 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Elderly people aged 60 to 85 years, with walking speed <0.8m / s (Guralnik, 1994).
排除标准
- •Elderly patients with uncontrolled diabetes mellitus or peripheral neuropathy;
- •Symptomatic peripheral obstructive arterial disease or brachial ankle index <0.9;
- •Uncontrolled arterial hypertension (BP> 160 / 100mmHg);
- •Uncontrolled dyslipidemia (total colostrum> 220mg / dL);
- •Infectious with less than 1 month;
- •Osteoarticular or neurological problems that prevent training;
- •History of anemia, cerebrovascular disease, myocardial infarction in the last 6 months;
- •Pior deep venous thrombosis;
- •Use of oral anticoagulant;
- •Smoking <6 months;
- •Use of antiplatelet agents and anticoagulants;
- •Cognitive dysfunctions: Mini-mental <
- •(Brucki, 2003).
结局指标
主要结局
Anthropometric Assessment
时间窗: Before and after 12 weeksof training
The body weight will be evaluated using the Filizola brand scale, with an accuracy of 0.1 kg. The stature will be obtained by means of the stadiometer coupled to the Filizola scale, with an accuracy of 0.5 cm. The BMI will be calculated from the weight ratio by height squared. For measures of circumference of the quadriceps, a tape measure of the brand Seca, with precision of 0.1 cm will be used. Anthropometric measurements will be made following the standardization of the International Society for Anthropometric Assessments (ISAK, 2001).
次要结局
- Tolerability, adherence and adverse effects(Before and after 12 weeks of training)
- Arterial pressure and heart rate(Before and after 12 weeks of training)
- Coagulation factors(Before and after 12 weeksof training)
- Speed Gait(Before and after 12 weeks of training)