NL-OMON45015已完成不适用
Blood pressure and cardiac output - the influence on cerebral perfusion during cardiopulmonary bypass. - Parameters of cerebral perfusion
niversitair Medisch Centrum Utrecht0 个研究点目标入组 32 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 32
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- age over 18 years
- •- undergoing cardiopulmonary bypass (CPB) for Coronary Artery Bypass Grafting (CABG)
- •- having an appropriate temporal bone window for reliable TCD monitoring
- •- needing pharmacological intervention because of hypotension before going on cardiopulmonary bypass.
排除标准
- •- requiring hypothermia during surgery
- •- requiring emergency surgery
- •- having a contraindication for phenylephrine
- •- having known brain pathology (e.g. Cerebral Vascular Accident (CVA) or increased intracranial pressure)
- •- having a history of severe carotid artery stenosis.
- •- having variations in hemodynamic parameters outside safe limits as described below, during the interventions
- •* The patient has no hypotension, defined as Mean Arterial Pressure (MAP) <60mmHg in the period before CPB
- •* Cardiac Output: change > 20%
- •* MAP: increase > 30mmHg
- •* Frontal lobe oxygenation (rSO2): a 20% bilateral or unilateral reduction from baseline values or an absolute decrease below 50%
- •* pH: <7.35 or >7.45
- •* Heart rate: <50 beats per minute or >80 beats per minute
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