Blood pressure and cardiac output - the influence on cerebral perfusion during cardiopulmonary bypass.

Completed

• Conditions: cerebral autoregulation; oxygen regulation of the brain; patienten aan de cardiopulmonale bypass

• Registration Number: NL-OMON45015
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 32

Inclusion Criteria

- age over 18 years
- undergoing cardiopulmonary bypass (CPB) for Coronary Artery Bypass Grafting (CABG)
- having an appropriate temporal bone window for reliable TCD monitoring
- needing pharmacological intervention because of hypotension before going on cardiopulmonary bypass.

Exclusion Criteria

- requiring hypothermia during surgery
- requiring emergency surgery
- having a contraindication for phenylephrine
- having known brain pathology (e.g. Cerebral Vascular Accident (CVA) or increased intracranial pressure)
- having a history of severe carotid artery stenosis.
- having variations in hemodynamic parameters outside safe limits as described below, during the interventions
* The patient has no hypotension, defined as Mean Arterial Pressure (MAP) <60mmHg in the period before CPB
* Cardiac Output: change > 20%
* MAP: increase > 30mmHg
* Frontal lobe oxygenation (rSO2): a 20% bilateral or unilateral reduction from baseline values or an absolute decrease below 50%
* pH: <7.35 or >7.45
* Heart rate: <50 beats per minute or >80 beats per minute

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary endpoints are the changes in the regional cerebral oxygen saturation<br /><br>and the mean velocity of bloodflow in the middle cerebral artery. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>