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Clinical Trials/NL-OMON45015
NL-OMON45015
Completed
Not Applicable

Blood pressure and cardiac output - the influence on cerebral perfusion during cardiopulmonary bypass. - Parameters of cerebral perfusion

niversitair Medisch Centrum Utrecht0 sites32 target enrollmentTBD
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Conditionspatienten aan de cardiopulmonale bypasscerebral autoregulationoxygen regulation of the brain

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
patienten aan de cardiopulmonale bypass
Sponsor
niversitair Medisch Centrum Utrecht
Enrollment
32
Status
Completed
Last Updated
2 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
2 years ago
Study Type
Interventional

Investigators

Sponsor
niversitair Medisch Centrum Utrecht

Eligibility Criteria

Inclusion Criteria

  • •\- age over 18 years
  • •\- undergoing cardiopulmonary bypass (CPB) for Coronary Artery Bypass Grafting (CABG)
  • •\- having an appropriate temporal bone window for reliable TCD monitoring
  • •\- needing pharmacological intervention because of hypotension before going on cardiopulmonary bypass.

Exclusion Criteria

  • •\- requiring hypothermia during surgery
  • •\- requiring emergency surgery
  • •\- having a contraindication for phenylephrine
  • •\- having known brain pathology (e.g. Cerebral Vascular Accident (CVA) or increased intracranial pressure)
  • •\- having a history of severe carotid artery stenosis.
  • •\- having variations in hemodynamic parameters outside safe limits as described below, during the interventions
  • •\* The patient has no hypotension, defined as Mean Arterial Pressure (MAP) \<60mmHg in the period before CPB
  • •\* Cardiac Output: change \> 20%
  • •\* MAP: increase \> 30mmHg
  • •\* Frontal lobe oxygenation (rSO2\): a 20% bilateral or unilateral reduction from baseline values or an absolute decrease below 50%

Outcomes

Primary Outcomes

Not specified

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