Effects on Blood Pressure, Cardio-Renal Function and Vascular Endothelial Function by HyperUricemia Treatment Study
Not Applicable
Recruiting
- Conditions
- Hyperuricemia
- Registration Number
- JPRN-UMIN000007350
- Lead Sponsor
- St. Lukes International Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Not provided
Exclusion Criteria
(1)Patients having anti-hyperuricemia medication (2)Patients with hypersensitivity to febuxostat (3)HbA1c is 8% and over (4)Patients with medication including NO donor (5)Hepatic impairment patients (AST, ALT is more than double of standard values) (6)Pregnant female, lactation femal, hoping gestation (7)Patients with corticosteroid 10mg/day and over (8)Treated patients with mercaptopurine or azathioprine (9)Patints having malignancy (10)Patients whom study physicians consider as not eligible.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Vascular endothelial function(flow mediated dilatation, pulse wave velocity, carotid intima-media thickness) 2. Cardio-renal function(NT-pro BNP, estimated GFR, cardiac echography) 3. Blood pressure
- Secondary Outcome Measures
Name Time Method 1. The change of serum uric acid 2. Ankle brachial index 3. Cytokine: 9-OhdG, MDA-LDL, CRP, IL-6, AGE, RAGE, NOx, Angintensin2, ADMA, IGF-alpha 4. Blood sugar, insulin, HbA1c, HOMA-beta 5. LDL-cholesterol, HDL-cholesterol, trigliceride 6. Blood test: BUN, creatinine, AST, ALT, LDH, ALP, sodium, potacium, cloride, homocystein 7. Urine test: uric acid, creatinin, sodium, potacium, cloride