New Criteria for Classifying Acute Respiratory Distress Syndrome Severity Using a Machine Learning Approach: Novel Oxygenation and Saturation Indices
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 2,000
- 试验地点
- 1
- 主要终点
- Oxygenation indices
研究概览
简要总结
This study aims to determine the cut-off values of the new oxygenation indices and further investigate their capabilities in diagnosing ARDS and predicting its severity in ICU. Additionally, the investigators aim to compare these results with conventional oxygenation and saturation indices.
详细描述
Recent studies have shown that mechanical power (MP) values below 17 J/min and driving pressure (DP) values below 15 cmH2O reduce intensive care unit (ICU) mortality. Asar et al. have introduced six new oxygenation indices utilizing MP and DP instead of Pmean (OSI-MPtot, OI-MPtot, OSI-ΔPinsp, OI-ΔPinsp, OSI-MPdyn, OI-MPdyn). They compared the predictive abilities of these new indices for ICU mortality in Covid-ARDS (C-ARDS) patients with conventional oxygenation indices (P/F, SpO2/FiO2, OI, OSI, PaO2/(FiO2xPEEP), and SpO2/FiO2xPEEP). OI-ΔPinsp, OSI-ΔPinsp, and OSI-MPdyn indices exhibited the highest predictive power for ICU mortality. However, cut-off values for the diagnosis and severity determination (mild, moderate, and severe) of ARDS patients have not been investigated.
In this study, our objective is to determine the cut-off values of the new oxygenation indices and further investigate their capabilities in diagnosing ARDS and predicting its severity in ICU. Additionally, the investigators aim to compare these results with conventional oxygenation and saturation indices.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients admitted to intensive care units diagnosed with ARDS / C-ARDS according to the Berlin criteria.
- •Adult patients aged between 18 and 80 years
排除标准
- •Patients under the age of 18
- •Pregnant patients
- •Patients without ARDS
- •Patients with missing data
- •Patients transferred to another hospital
- •Patients discharged from the ICU within 72 hours
- •Patients receiving extracorporeal membrane oxygenation (ECMO) support.
- •Patients were on mechanical ventilation for less than 24 hours
结局指标
主要结局
Oxygenation indices
时间窗: During 28 days in the intensive care unit
It was aimed to compare the oxygenation indexes of the patients. It will be examined which of these indices is more effective in diagnosing ARDS.
次要结局
- arterial blood gas parameters(During 28 days in the intensive care unit)
- acute physiology and chronic health evaluation-II(During 28 days in the intensive care unit)
- Other parameters(During 28 days in the intensive care unit)
- Charlson comorbidity index scores(During 28 days in the intensive care unit)
研究者
Furkan Tontu
Doctor of Anesthesiology and Reanimation
Başakşehir Çam & Sakura City Hospital