The Effect of Non-surgical Periodontal Therapy on the Gingival Crevicular Fluid Levels of Prolactin Hormone in Patients With Periodontitis.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- prolactin in GCF
研究概览
简要总结
The present study will be conducted on fifty participants. All participants will receive a full-mouth clinical examination, and the following periodontal parameters will be recorded: Plaque Index (PI). Gingival Index (GI), probing depth (PD), and clinical attachment level (CAL). All of these measurements will be recorded at six sites at baseline for all participants and 3 months after non-surgical periodontal therapy for the study group. GCF samples will be collected from the buccal aspects of teeth that had the highest signs of inflammation and attachment loss for periodontitis group at baseline and 3 months after non-surgical periodontal therapy. As for controls, the samples will be collected from buccal aspect of upper first molar at baseline. The samples will be assayed for prolactin by using an enzyme linked immunosorbent assay kits (Elisa) according to the manufacturer instruction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects with moderate to severe chronic periodontitis, with probing pocket depth (PPD) ≥ 4-6 mm and clinical attachment level ≥ 4-5 mm, according to the American Academy of Periodontology.7
- •Highly motivated and cooperative patients
排除标准
- •The presence of any systemic disease.
- •Taking medications for the last 3 months before conducting this study.
- •Pregnancy and lactation.
- •Any type of previous periodontal treatment (surgical or non-surgical) in the preceding 6 months.
- •Smoking (former or current).
研究组 & 干预措施
periodontitis group
in this group, prolactin in GCF will be assessed at baseline and after 3 months of receiving non-surgical periodontal treatment
干预措施: non-surgical periodontal therapy (Procedure)
control group
in this group of systemically and periodontally healthy participants, prolactin in GCF will be assessed at baseline only
结局指标
主要结局
prolactin in GCF
时间窗: 3 months
prolactin level in GCF by ELISA
次要结局
未报告次要终点
研究者
Eman Mohamed Amr
Associate Professor of Oral Medicine and Periodontology
Cairo University