Dexmedetomidine Affect Diabetic Patient's Glucose Metabolism
- Registration Number
- NCT02510612
- Lead Sponsor
- Shaanxi Provincial People's Hospital
- Brief Summary
Dexmedetomidine's Sedative Effect on Diabetic Patient
- Detailed Description
Dexmedetomidine is a high selective α2 agonist,its sedative and analgesia feature is acclaimed. The pathogenesis of type 2 diabetes mellitus is associated with α2 excessive adrenaline receptors expression. This study is to evaluate whether the use of dexmedetomidine is helpful to Diabetic Patient through its antisympathetic effect
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 120
- Age between 40 and 60
- Selective epigastrium surgery
- In
- American Society of Anesthesiology (ASA) Physical Status>3
- Duration of operation >3 hours
- Hypovolemia,sinus bradycardia,atrioventricular block,severe hepatic and renal dysfunction,severe cardiac insufficiency
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description placebo placebo Patients in group P will be given normal saline during anesthesia induction and maintenance phase Dexmedetomidine Dexmedetomidine Patients in group D will be given dexmedetomidine during anesthesia induction and maintenance phase respectively.In induction phase infuse 1μg/Kg of dexmedetomidine in 10 minutes， the speed in maintenance phase is 0.4μg/Kg.h
- Primary Outcome Measures
Name Time Method sedation level from 5 minutes before medication to 10 minutes after Dexmedetomidine discontinuance，length of time frame is about 2 hours Ramsay score and BIS will be recorded before medication,5 min after medication, medication ending, 5 and 10 min after medication
- Secondary Outcome Measures
Name Time Method Mean arterial pressure participants will be followed from operation day to first postoperative day，an expected average of 2 days 10 min after medication, before intubation, after intubation, after skin incision,60 minutes after skin incision, after extubation,first day after operation
cortisol measured by Biochemical test participants will be followed from operation day to first postoperative day，an expected average of 2 days it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation
adrenaline measured by Biochemical test participants will be followed from operation day to first postoperative day，an expected average of 2 days it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation
noradrenaline measured by Biochemical test participants will be followed from operation day to first postoperative day，an expected average of 2 days it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation
blood glucose measured by Biochemical test participants will be followed from operation day to first postoperative day，an expected average of 2 days it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation
Heart rate participants will be followed from operation day to first postoperative day，an expected average of 2 days recorded at before medication,5 min after medication, medication ending, 5 and 10 min after medication, before intubation, after intubation, after skin incision,60 minutes after skin incision, after extubation,first day after operation
insulin measured by Biochemical test participants will be followed from operation day to first postoperative day，an expected average of 2 days it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation