Perioperative Dexmedetomidine Affect Diabetic Patient's Glucose Metabolism
试验速览
- 阶段
- 4 期
- 入组人数
- 120
- 主要终点
- sedation level
研究概览
简要总结
Dexmedetomidine's Sedative Effect on Diabetic Patient
详细描述
Dexmedetomidine is a high selective α2 agonist,its sedative and analgesia feature is acclaimed. The pathogenesis of type 2 diabetes mellitus is associated with α2 excessive adrenaline receptors expression. This study is to evaluate whether the use of dexmedetomidine is helpful to Diabetic Patient through its antisympathetic effect
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 40 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 40 and 60
- •Selective epigastrium surgery
排除标准
- •American Society of Anesthesiology (ASA) Physical Status>3
- •Duration of operation >3 hours
- •Hypovolemia,sinus bradycardia,atrioventricular block,severe hepatic and renal dysfunction,severe cardiac insufficiency
研究组 & 干预措施
Dexmedetomidine
Patients in group D will be given dexmedetomidine during anesthesia induction and maintenance phase respectively.In induction phase infuse 1μg/Kg of dexmedetomidine in 10 minutes， the speed in maintenance phase is 0.4μg/Kg.h
干预措施: Dexmedetomidine (Drug)
placebo
Patients in group P will be given normal saline during anesthesia induction and maintenance phase
干预措施: placebo (Drug)
结局指标
主要结局
sedation level
时间窗: from 5 minutes before medication to 10 minutes after Dexmedetomidine discontinuance，length of time frame is about 2 hours
Ramsay score and BIS will be recorded before medication,5 min after medication, medication ending, 5 and 10 min after medication
次要结局
- Mean arterial pressure(participants will be followed from operation day to first postoperative day，an expected average of 2 days)
- cortisol measured by Biochemical test(participants will be followed from operation day to first postoperative day，an expected average of 2 days)
- adrenaline measured by Biochemical test(participants will be followed from operation day to first postoperative day，an expected average of 2 days)
- noradrenaline measured by Biochemical test(participants will be followed from operation day to first postoperative day，an expected average of 2 days)
- blood glucose measured by Biochemical test(participants will be followed from operation day to first postoperative day，an expected average of 2 days)
- Heart rate(participants will be followed from operation day to first postoperative day，an expected average of 2 days)
- insulin measured by Biochemical test(participants will be followed from operation day to first postoperative day，an expected average of 2 days)
研究者
Song yulong
Anesthetist
Shaanxi Provincial People's Hospital