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Clinical Trials/NCT00436306
NCT00436306
Completed
Phase 4

Stage Matched Intervention to Increase Dual Method Use

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)1 site in 1 country550 target enrollmentOctober 1999

Overview

Phase
Phase 4
Intervention
Not specified
Conditions
Contraception
Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Enrollment
550
Locations
1
Primary Endpoint
Behavioral: reported use of dual methods of contraception
Status
Completed
Last Updated
10 years ago

Overview

Brief Summary

The primary purpose of Project PROTECT was to evaluate two different intervention approaches that encourage young women to use dual methods of contraception. The individualized intervention is a computer assisted, fully-tailored, interactive intervention based on the transtheoretical model of behavior change. This intervention was compared to an enhanced standard care intervention that provided computer-based, non-tailored information and advice regarding the use of contraceptive methods. The two primary outcomes of this trial include: 1) a behavioral outcome: the reported use of dual methods of contraception; and 2) a biological outcome: an incident or recurrent STI or unintended pregnancy. The hypotheses of this trial were: 1) the individualized intervention will result in a greater increase in dual contraceptive use than the standard care approach; and 2) the individualized intervention would result in greater protection against incident or recurrent cases of sexually transmitted infections and unplanned pregnancies.

Detailed Description

Protection from both sexually transmitted infections (STIs), human immunodeficiency virus (HIV), and unintended pregnancy can be achieved with the use of dual methods of contraception. This proposal was designed to develop, implement, and evaluate the impact of an innovative, computer-assisted stage-based individualized interactive intervention (Individualized Intervention) based on the transtheoretical compared to enhanced standard care counseling on the use of dual methods of contraception. Primary outcomes, including behavioral and biological outcomes, were assessed in this randomized clinical trial of 550 high-risk women. Participants were followed at 6 month intervals for 24 months with follow-up interviews to determine reported use of dual methods of contraception (behavioral outcome). Clinical examinations at 12 and 24 months and with new onset of symptoms assessed biological outcomes including incident or recurrent cases of STI and unintended pregnancy. Secondary outcomes included intermediate outcome variables such as changes in stage of change, processes of change, decisional balance, and self-efficacy. The primary hypotheses of this study were: 1. the Individualized Intervention will result in increased dual contraceptive use; 2. the Individualized Intervention will result in protection against new cases of STIs, re-infection with sexually transmitted organisms, and unplanned pregnancies; and 3. the Individualized Intervention will lead to the greatest changes in secondary outcome measures. If found to be effective, the stage-matched intervention has potential for widespread dissemination in schools, clinics, offices, and community centers to prevent STIs/HIV and unintended pregnancy.

Registry
clinicaltrials.gov
Start Date
October 1999
End Date
December 2005
Last Updated
10 years ago
Study Type
Interventional
Study Design
Parallel
Sex
Female

Investigators

Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Responsible Party
Principal Investigator
Principal Investigator

Jeffrey Peipert

Robert J. Terry Professor

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Eligibility Criteria

Inclusion Criteria

  • English-speaking
  • Sexually active with a male partner in the past 6 months
  • Desire to avoid conception for 24 months or more
  • High risk for unintended pregnancy or STI:
  • Age less than 25
  • Age 25 and older with:
  • History of unplanned pregnancy
  • History of a sexually transmitted infection
  • Inconsistent use of contraception
  • Other factors felt to place a patient at above average risk for unplanned pregnancy or STI

Exclusion Criteria

  • currently using dual methods of contraception consistently and correctly.
  • incompetent or unable to give consent;
  • currently pregnant or desires pregnancy in the next 24 months.

Outcomes

Primary Outcomes

Behavioral: reported use of dual methods of contraception

Time Frame: 24 months

Outcome: ANY use of dual methods of contraception. Also evaluated consistent condom use.

Biological: incident sexually transmitted infection or unintended pregnancy

Time Frame: 24 months

ANY sexually transmitted infection OR unintended pregnancy.

Secondary Outcomes

  • Secondary outcomes will include intermediate outcomes variables such as(24 months)
  • changes in stage of change, processes of change, decisional balance, and self-efficacy.(24 months)

Study Sites (1)

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