Prospective Comparison of Immunological Benefit of Laparoscopic Colectomy
Completed
- Conditions
- Immunity
- Registration Number
- NCT00744159
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
This study aimed to clarify existence of immunological benefit of laparoscopic colon cancer surgery compared to open colon surgery.
- Detailed Description
Patients with clinical stage Ⅲ left colon and upper rectal cancer were prospectively assigned to undergo LC (n=35) or OC (n=39). Factors related to cellular immunity of host (total lymphocyte count, CD4 lymphocyte, CD8 lymphocyte, CD4/CD8 ratio, HLA-DR expression on monocyte (mHLA-DR)) were examined preoperatively, on the 1st day of operation (POD1) and the 5th day of operation (POD5).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 84
Inclusion Criteria
- Biopsy proven of colon cancer
- Preoperatively suspected as clinical stage III colon cancer
- Lesion located Descending colon, sigmoid colon and upper rectal cancer
Exclusion Criteria
- Could not perform curative resection
- Intestinal obstruction, perforation, intra-abdominal abscess
- Severe medical illness
- Immunopathy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Immune factors post OP 5th day
- Secondary Outcome Measures
Name Time Method Post-operative complications POD 7th days
Trial Locations
- Locations (1)
Samsung Medical Center, Department of surgery
🇰🇷Seoul, Korea, Republic of