Functional Brain Imaging - Acupuncture and Osteoarthritis

Phase 2

Completed

• Conditions: Osteoarthritis

• Registration Number: NCT00070824
• Lead Sponsor: National Center for Complementary and Integrative Health (NCCIH)

Brief Summary

The goal of this study is to use single photon emission computed tomography (SPECT) and functional magnetic resonance imaging (f-MRI) of the brain to study the response of both normal participants and participants with Osteoarthritis (OA) of the knee to acupuncture.

Detailed Description

Recent experimental studies in both animal and humans have begun to demonstrate some measurable physiologic effects that are associated with acupuncture, suggesting the possibility of a neurophysiologic explanation. In addition, brain research continues to uncover a complex set of endogenous neurologic control systems, such that it has become clear that the brain plays a major role in the modulation of pain perception and control. If acupuncture can be demonstrated to have a consistent effect on specific areas of the brain, it will become possible to explore the potential efficacy of acupuncture based on measurable neurophysiologic responses.

Study Timeline

• Study First Submitted: 2003-10-08
• Study First Submitted QC: 2003-10-10
• Study First Posted: 2003-10-13
• Study Start: 2004-01
• Study Completion: 2007-04
• Status Verified: 2007-09
• Last Update Submitted: 2007-09-06
• Last Update Posted: 2007-09-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
SPECT Cerebral Bloodflow	24 hours

Secondary Outcome Measures

Name	Time	Method
0-10 Numeric Rating Scale for Pain Intensity	1 hour

Trial Locations

Locations (1)

Hospital of the University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States