Fertility Study of Women With Chronic Inflammatory Rheumatism
- Conditions
- Arthritis, RheumatoidChronic Juvenile ArthritisAnkylosing SpondylitisArthritis, Psoriatic
- Interventions
- Other: Questionnaire about fertility
- Registration Number
- NCT03452735
- Lead Sponsor
- University Hospital, Toulouse
- Brief Summary
Etiopathogenesis of Chronic inflammatory rheumatisms (CIR) includes genetic, autoimmune and environmental factors. Their impact on the quality of life is important, leading to a sometimes severe disability. Thus they are likely to affect female fertility through several mechanisms, including autoimmune since the association between immunity and fertility has already been demonstrated in other autoimmune diseases.
This study wants to evaluate and compare the birth rate between CIR and control group.
- Detailed Description
Data collection will be carried out using a questionnaire submitted to women in charge of the rheumatology department of the University Hospital of Toulouse and having agreed to participate:
* women with Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis or Chronic juvenile arthritis for the chronic inflammatory rheumatism group
* women with a mechanical rheumatic pathology for the control group
The primary endpoint was birth rate after spontaneous or induced pregnancy in patients who attempted to procreate, in the CIR group and in the control group.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 2900
- Patient with Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis, Chronic juvenile arthritis, Chronic Inflammatory Rheumatism
- Patient diagnosed before the age of 40
- Patient having given her no opposition to her participation in research
- For the control group: patient not suffering from chronic inflammatory rheumatism, having consulted in Rheumatology for a mechanical pathology
- Patient> 40 years old at the time of diagnosis
- Patient with insufficient medical data (treatments)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Control Group Questionnaire about fertility Patient between the ages of 18 and 50 years, not diagnosed with Chronic inflammatory rheumatism, having consulted in Rheumatology for a mechanical pathology, presenting no chronic pathology, having no chemo or radiotherapy or immunosuppressive therapy, or pelvic surgery before age 40 years who will answer to a questionnaire about fertility patients diagnosed before age 40 Questionnaire about fertility Patient between 18 and 50 years-old with Rheumatoid arthritis, Psoriatic arthritis, Ankylosing spondylitis, Chronic juvenile arthritis, Chronic Inflammatory Rheumatism who will answer to a questionnaire about fertility
- Primary Outcome Measures
Name Time Method Birth rate after spontaneous or induced pregnancy One day Birth rate after spontaneous or induced pregnancy in women who have tried to procreate in the chronic inflammatory rheumatism group and in the control group.
- Secondary Outcome Measures
Name Time Method Birth rate according to the treatments used One day Birth rate in the CIR group according to the treatments used
Design time One day Design time in the CIR group and in the control group
Rates of ectopic pregnancy, early or late spontaneous miscarriage one day Rates of ectopic pregnancy, early or late spontaneous miscarriage, early or late pregnancy, children born dead, preterm birth in the CIR group and in the control group
Rates of desire for pregnancy One day Rates of desire for pregnancy and study of the reasons for this lack of desire for pregnancy in the CIR group and in the control group
Birth rate according to the activity of the disease One day Birth rate in the CIR group according to the activity of the disease
Rates of sexual dysfunction One day Rates of sexual dysfunction in the CIR group and in the control group
Trial Locations
- Locations (1)
University Hospital Toulouse
🇫🇷Toulouse, France