Speech Entrainment for Aphasia Recovery
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Aphasia
- Sponsor
- Medical University of South Carolina
- Enrollment
- 80
- Locations
- 3
- Primary Endpoint
- Average Verbs Per Minute (VPM) Change From Baseline
- Status
- Completed
- Last Updated
- 5 months ago
Overview
Brief Summary
After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced speech production, with the speaker producing only a few words or even less. Speech entrainment therapy (SET) is a treatment that has been shown to increase fluency in people with non-fluent aphasia. The study looks to define the best dose of SET that leads to sustained improvements in spontaneous speech production.
Participants who are eligible will undergo baseline language testing, an MRI, and will be randomized into one of 4 treatment groups: SET for 3 weeks, SET for 4.5 weeks, SET for 6 weeks, and no treatment (control group).
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Average Verbs Per Minute (VPM) Change From Baseline
Time Frame: 3 months after treatment (or no treatment)
VPM will be assessed through procedural storytelling and narrative storytelling tasks - with four items in each category. The procedural storytelling items are: 1) how to make a peanut butter and jelly sandwich, 2) how to make scrambled eggs, 3) how to brew coffee, and 4) how to wash dishes. The narrative items will be: 1) Cinderella story, 2) Little Red Riding Hood, 3) The Three Little Pigs, and 4) Goldilocks. VPM is averaged between the procedural storytelling and narrative storytelling tasks.
Secondary Outcomes
- Stroke and Aphasia Quality of Life Scale-39 (SAQOL-39) Change From Baseline(3 months after treatment (or no treatment))
- Narrative Verbs Per Minute (VPM)(3 months after treatment (or no treatment))
- Procedural Verbs Per Minute (VPM) Change From Baseline(3 months after treatment (or no treatment))