The Effect of Aerobic Exercise on Genetic Molecules Related With Metabolism
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Diabetes Mellitus, Type 2
- Sponsor
- Pamukkale University
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- genetic molecules
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The aim of this study is to compare the effects of high intensity interval exercise and moderate intensity continuous exercise on some genetic molecules in patients with type 2 diabetes mellitus.
Detailed Description
Volunteers with type 2 diabetes mellitus will be evaluated in terms of any contra-indication that will restrain them from making exercise. 90 male or female volunteers who are suitable in terms of inclusion/exclusion criteria will be invited for the study. Volunteers will be randomly distributed to one of the 3 groups. Each group will contain 30 participants. 1. group will make aerobic exercise which is in the form of high intensity interval exercise 2.group will make aerobic exercise which is in the form of moderate intensity continuous exercise 3. Control group. Exercise groups will be cycling under observation in the hospital setting. Control group will make simple stretching exercises at home. Participants will be requested to complete a 3 months of exercise. They will be evaluated before and at the end of the 3 months of exercise with blood tests to measure genetic molecules related with metabolism.
Investigators
GULIN FINDIKOGLU
Associate Professor
Pamukkale University
Eligibility Criteria
Inclusion Criteria
- •Clinica diagnosis of type 2 Diabetes mellitus less than 10 years and more than 1 year.
- •must have appropriate medical therapy and diet.
- •must not be treated with insulin.
- •must be exercising less than 210 minutes/ week
Exclusion Criteria
- •prominent cardiovascular disease
- •coronary artery disease
- •moderate to severe valvular disease
- •atrial fibrillation
- •untreated hypertension
- •congenital heart disease
- •retinopathy
- •neuropathy
- •macro albuminuria
- •cerebrovascular disease
Outcomes
Primary Outcomes
genetic molecules
Time Frame: 12 weeks
HbA1c level in the serum