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Clinical Trials/NL-OMON49528
NL-OMON49528
Recruiting
Not Applicable

Pharmacokinetic and pharmacodynamic target attainment of amoxicillin(-clavulanic acid) in pleural empyema fluid and complicated parapneumonic effusion - Empyema-study

Academisch Medisch Centrum0 sites20 target enrollmentTBD
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Conditionspleural effusionPus in the area between the lungs10004018

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
pleural effusion
Sponsor
Academisch Medisch Centrum
Enrollment
20
Status
Recruiting
Last Updated
2 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
2 years ago
Study Type
Observational invasive

Investigators

Eligibility Criteria

Inclusion Criteria

  • •Age \>\= 18 years
  • •Diagnosed with pleural empyema or complicated parapneumonic effusion, based on
  • •the criteria mentioned below, and in need of pleural fluid drainage.
  • •o presence of pus or positive Gram\*s stain or culture from the pleural fluid.
  • •o pleural pH\<7\.2 or pleural fluid glucose value \<2\.2 mmol/l or pleural fluid
  • •LDH value \>1000 IU/L
  • •Receiving IV amoxicillin 1000mg 4 times daily or amoxicillin\-clavulanic acid
  • •1000/200mg 4 times daily; dosage if necessary adapted to renal function
  • •Able and willing to give informed consent (or consent by family member or legal
  • •representative)

Exclusion Criteria

  • •Critically ill patients admitted to the ICU, or patients of the general ward
  • •who became critically ill and got transferred to the ICU during the duration of
  • •Pre\-existing ipsilateral pleural effusion or other cause of pleural effusion
  • •(e.g. cancer) more likely.

Outcomes

Primary Outcomes

Not specified

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