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Clinical Trials/NL-OMON24554
NL-OMON24554
Not yet recruiting
Not Applicable

Pharmacokinetic and pharmacodynamic target attainment of amoxicillin(-clavulanic acid) in pleural empyema fluid and complicated parapneumonic effusion

ot applicable.0 sites20 target enrollmentTBD
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Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Not specified
Sponsor
ot applicable.
Enrollment
20
Status
Not yet recruiting
Last Updated
2 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
2 years ago
Study Type
Observational non invasive

Investigators

Sponsor
ot applicable.

Eligibility Criteria

Inclusion Criteria

  • •Age \= 18 years
  • •\-Diagnosed with pleural empyema or complicated parapneumonic effusion, based on the criteria mentioned below, and in need of pleural fluid drainage.
  • •opresence of pus or positive Gram’s stain or culture from the pleural fluid.
  • •opleural pH\<7\.2 or pleural fluid glucose value \<2\.2 mmol/l or pleural fluid LDH value \>1000 IU/L
  • •\-Receiving IV amoxicillin 1000mg 4 times daily or amoxicillin\-clavulanic acid 1000/200mg 4 times daily; dosage if necessary adapted to renal function
  • •\-Able and willing to give informed consent (or consent by family member or legal representative)

Exclusion Criteria

  • •\-Critically ill patients admitted to the ICU, or patients of the general ward who became critically ill and got transferred to the ICU during the duration of the study.
  • •\-Pre\-existing ipsilateral pleural effusion or other cause of pleural effusion (e.g. cancer) more likely.

Outcomes

Primary Outcomes

Not specified

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