Contrast enhanced ultrasound to measure cerebral blood flow
Completed
- Conditions
- acute brain injuryacute cerebral ischemia10007963
- Registration Number
- NL-OMON42396
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Healthy men or women of 18-35 years old
Exclusion Criteria
Hypersensitivity to the active substance(s) or to any of the excipients in SonoVue
Right-to-left shunt cardiac shunt
Severe pulmonary hypertension (pulmonary artery pressure >90 mmHg)
Uncontrolled systemic hypertension
Pregnancy
Lactation
Participation in another clinical trial within 3 months prior to the experimental day.
History, signs, or symptoms of cardiovascular disease or pulmonary disease
History, signs or symptoms of neurological disease
History of hyperventilation
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Main study parameter is the reproducibility of the CEUS bolus kinetics and the<br /><br>flash-replenishment method. A difference between the measurements of more than<br /><br>10% is considered to imply poor reproducibility. As a control, the<br /><br>reproducibility of measurement of the flow velocity in the ipsilateral middle<br /><br>cerebral artery will be assessed. . </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameters are 1) Correlation between the bolus kinetics<br /><br>approach and the flash-replenishment method and 2) Comparison of the CEUS bolus<br /><br>technique with transcranial Doppler (at 2 different levels of cerebral blood<br /><br>flow</p><br>