The Effect of Food Supplements on Food Intake and Gut Hormone Levels

Not Applicable

Completed

• Conditions: Obesity; Appetite; Perverted; Endocrine; Obesity

• Registration Number: NCT04292236
• Lead Sponsor: Queen Mary University of London

Brief Summary

When a meal is eaten, nutrients activate the release of hormones from the bowel into the blood stream. Normally there is a large amount of hormone released, which tells the brain that an individual is full and to stop eating. When people gain weight and become overweight or obese, these hormone signals are reduced, resulting in these people eating more and gaining more weight. This study is investigating mechanisms which may break this cycle by using particular nutrients to restore reduced hormone levels.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-02-22
• Primary Completion: 2019-07-22
• Study Completion: 2019-07-22
• Status Verified: 2020-02
• Study First Submitted: 2020-02-20
• Study First Submitted QC: 2020-02-27
• Last Update Submitted: 2020-02-27
• Study First Posted: 2020-03-03
• Last Update Posted: 2020-03-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Obese but otherwise healthy volunteers,
• body mass index (BMI) of 30-40 kg/m2
• agreement to consume scheduled meals
• ability to understand the study information sheet and instructions in English and able to provide informed consent.

Exclusion Criteria

• Not meeting any of the exclusion criteria above.
• Major gut surgery
• Major health problems
• Taking medication for diabetes

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Effect on appetite and satiety ratings	Study day 1 and study day 2 (following meal intake at breakfast and lunch)	Effect on appetite measured as change in calorific intake

Secondary Outcome Measures

Name	Time	Method
Effect on satiety scores	Study day 1 and study day 2 (following meal intake at breakfast and lunch)	Using a visual analogue scale measuring changes to hunger, satiety and fullness scores
Effect on gut hormone levels	Study day 1 and study day 2 with samples taken every 30 min	Assess changes to circulating levels of anorectic hormones GLP-1, PYY and orexigenic hormone Ghrelin.

Trial Locations

Locations (1)

Queen Mary University of Queensland; 🇬🇧 London, United Kingdom